The microtubule cytoskeleton is critical for maintenance of long and long-lived neurons. The
overlapping array of microtubules extends from the major site of synthesis in the cell body to …

Many neurons in bilaterian animals are polarized with functionally distinct axons and
dendrites. Microtubule polarity, microtubule stability, and the axon initial segment (AIS) have …

Highlights•Reactivate intrinsic growth programs after injury can promote neurite
repair.•Repair of secondary damage upon injury is critical for full functional …

While many regulators of axon regeneration have been identified, very little is known about
mechanisms that allow dendrites to regenerate after injury. Using a Drosophila model of …

Kinetochores connect centromeric chromatin to spindle microtubules during mitosis.
Neurons are postmitotic, so it was surprising to identify transcripts of structural kinetochore …

The exocyst complex is an important regulator of intracellular trafficking and tethers
secretory vesicles to the plasma membrane. Understanding of its role in neuron outgrowth …

Dendrites are injured in a variety of clinical conditions such as traumatic brain and spinal
cord injuries and stroke. How neurons detect injury directly to their dendrites to initiate a pro …

Most neurons are not replaced after injury and thus possess robust intrinsic mechanisms for
repair after damage. Axon injury triggers a calcium wave, and calcium and cAMP can …

Axon regeneration helps maintain lifelong function of neurons in many animals. Depending
on the site of injury, new axons can grow either from the axon stump (after distal injury) or …

A fundamental feature of nervous systems is a highly specified synaptic connectivity
between cells and the ability to adaptively change this connectivity through plasticity …