Natural products as anticancer agents: current status and future perspectives

A Naeem, P Hu, M Yang, J Zhang, Y Liu, W Zhu… - Molecules, 2022 - mdpi.com
Natural products have been an invaluable and useful source of anticancer agents over the
years. Several compounds have been synthesized from natural products by modifying their …

A comprehensive review of rosmarinic acid: From phytochemistry to pharmacology and its new insight

H Guan, W Luo, B Bao, Y Cao, F Cheng, S Yu, Q Fan… - Molecules, 2022 - mdpi.com
Polyphenolic acids are the widely occurring natural products in almost each herbal plant,
among which rosmarinic acid (RA, C18H16O8) is well-known, and is present in over 160 …

[HTML][HTML] Rosmarinic acid and its derivatives: Current insights on anticancer potential and other biomedical applications

S Ijaz, J Iqbal, BA Abbasi, Z Ullah, T Yaseen… - Biomedicine & …, 2023 - Elsevier
Cancer is still the leading cause of death worldwide, burdening the global medical system.
Rosmarinic acid (RA) is among the first secondary metabolites discovered and it is a …

Recent updates on anticancer mechanisms of polyphenols

E Sharma, DC Attri, P Sati, P Dhyani… - Frontiers in Cell and …, 2022 - frontiersin.org
In today's scenario, when cancer cases are increasing rapidly, anticancer herbal
compounds become imperative. Studies on the molecular mechanisms of action of …

An Update on the Therapeutic Anticancer Potential of Ocimum sanctum L.: “Elixir of Life”

MR Hasan, BS Alotaibi, ZM Althafar, AH Mujamammi… - Molecules, 2023 - mdpi.com
In most cases, cancer develops due to abnormal cell growth and subsequent tumour
formation. Due to significant constraints with current treatments, natural compounds are …

[HTML][HTML] Unraveling the function of epithelial-mesenchymal transition (EMT) in colorectal cancer: Metastasis, therapy response, and revisiting molecular pathways

E Sabouni, MM Nejad, S Mojtabavi… - Biomedicine & …, 2023 - Elsevier
Colorectal cancer (CRC) is a dangerous form of cancer that affects the gastrointestinal tract.
It is a major global health concern, and the aggressive behavior of tumor cells makes it …

Rosmarinic acid‐crosslinked supramolecular nanoassembly with self‐regulated photodynamic and anti‐metastasis properties for synergistic photoimmunotherapy

Y Zhou, Y Zhang, C Jiang, Y Chen, F Tong, X Yang… - Small, 2023 - Wiley Online Library
A primary concern about photodynamic therapy (PDT) is its inability to regulate the
generation levels of reactive oxidative species (ROS) based on the complex …

[HTML][HTML] Rosmarinic acid alleviates cardiomyocyte apoptosis via cardiac fibroblast in doxorubicin-induced cardiotoxicity

X Zhang, JX Zhu, ZG Ma, HM Wu, SC Xu… - … Journal of Biological …, 2019 - ncbi.nlm.nih.gov
Cardiomyocyte apoptosis is a key event in the process of doxorubicin (DOX)-induced
cardiotoxicity. Our previous study found that rosmarinic acid (RA) could attenuate pressure …

Anticancer potential of rosmarinic acid and its improved production through biotechnological interventions and functional genomics

MK Swamy, UR Sinniah, A Ghasemzadeh - Applied microbiology and …, 2018 - Springer
Rosmarinic acid (RA) is a highly valued natural phenolic compound that is very commonly
found in plants of the families Lamiaceae and Boraginaceae, including Coleus blumei …

Rosmarinic acid and related dietary supplements: Potential applications in the prevention and treatment of cancer

J Zhao, L Xu, D Jin, Y Xin, L Tian, T Wang, D Zhao… - Biomolecules, 2022 - mdpi.com
Cancer constitutes a severe threat to human health and quality of life and is one of the most
significant causes of morbidity and mortality worldwide. Natural dietary products have drawn …