Antibiotic-induced collateral damage to the microbiota and associated infections

L de Nies, CM Kobras, M Stracy - Nature Reviews Microbiology, 2023 - nature.com
Antibiotics have transformed medicine, saving millions of lives since they were first used to
treat a bacterial infection. However, antibiotics administered to target a specific pathogen …

Update on the adverse effects of antimicrobial therapies in community practice

S Mohsen, JA Dickinson, R Somayaji - Canadian Family Physician, 2020 - cfp.ca
Objective To gather information about antibiotic side effects to be used as a reference and
learning resource for prescribing physicians. Quality of evidence A search of websites of …

A Pharmacovigilance Study Regarding the Risk of Antibiotic-Associated Clostridioides difficile Infection Based on Reports from the EudraVigilance Database …

BI Vintila, AM Arseniu, C Morgovan, A Butuca, M Sava… - Pharmaceuticals, 2023 - mdpi.com
The Gram-positive anaerobic bacterium Clostridioides difficile (CD) can produce intense
exotoxins, contributing to nosocomial infections, and it is the most common cause of health …

Multi-omics investigation of Clostridioides difficile-colonized patients reveals pathogen and commensal correlates of C. difficile pathogenesis

SRS Fishbein, JI Robinson, T Hink, KA Reske… - Elife, 2022 - elifesciences.org
Clostridioides difficile infection (CDI) imposes a substantial burden on the health care
system in the United States. Understanding the biological basis for the spectrum of C …

Adverse reactions associated with penicillins, carbapenems, monobactams, and clindamycin: a retrospective population-based study

EH Liang, LH Chen, E Macy - The Journal of Allergy and Clinical …, 2020 - Elsevier
Background Limited population-based data on penicillin-, carbapenem-, monobactam-, and
clindamycin-associated reported adverse reactions exist. Objective To collect data on …

Fournier gangrene associated with sodium‐glucose cotransporter‐2 inhibitors: a pharmacovigilance study with data from the US FDA Adverse Event Reporting …

Y Hu, Z Bai, Y Tang, R Liu, B Zhao… - Journal of Diabetes …, 2020 - Wiley Online Library
Background. The US Food and Drug Administration (FDA) released a safety warning of
Fournier gangrene (FG), a rare but serious adverse effect of sodium‐glucose cotransporter …

Antibiotic-Specific Risk for Community-Acquired Clostridioides difficile Infection in the United States from 2008 to 2020

J Zhang, L Chen, A Gomez-Simmonds… - Antimicrobial Agents …, 2022 - Am Soc Microbiol
Antibiotic exposure is a crucial risk factor for community-acquired Clostridioides difficile
infection (CA-CDI). However, the relative risks associated with specific antibiotics may vary …

Antibiotics and adverse events: the role of antimicrobial stewardship programs in 'doing no harm'

KA Bauer, R Kullar, M Gilchrist… - Current opinion in …, 2019 - journals.lww.com
Currently, there is a significant gap in ASPs correlating initiatives with patient safety goals,
including reductions in antibiotic-associated ADEs and multidrug-resistant infections …

Targeting Clostridioides difficile: New uses for old drugs

J Chen, Y Li, S Wang, H Zhang, Y Du, Q Wu… - Drug Discovery …, 2022 - Elsevier
Clostridioides difficile bacteria can cause life-threatening diarrhea and colitis owing to
limited treatment options and unacceptably high recurrence rates among infected patients …

Comparing acute kidney injury reports among antibiotics: a pharmacovigilance study of the FDA adverse event reporting system (FAERS)

TM Patek, C Teng, KE Kennedy, CA Alvarez, CR Frei - Drug Safety, 2020 - Springer
Background A study using the US FDA Adverse Event Reporting System (FAERS) found
significant acute kidney injury (AKI) reporting associations with vancomycin …