Influence of follicular fluid and cumulus cells on oocyte quality: clinical implications
MG Da Broi, VSI Giorgi, F Wang, DL Keefe… - Journal of assisted …, 2018 - Springer
An equilibrium needs to be established by the cellular and acellular components of the
ovarian follicle if developmental competence is to be acquired by the oocyte. Both cumulus …
ovarian follicle if developmental competence is to be acquired by the oocyte. Both cumulus …
[HTML][HTML] Cyclooxygenase-2 in endometriosis
ZZ Lai, HL Yang, SY Ha, KK Chang, J Mei… - … journal of biological …, 2019 - ncbi.nlm.nih.gov
Endometriosis (EMS) is the most common gynecological disease in women of reproductive
age, and it is associated with chronic pelvic pain, dyspareunia and infertility. As a …
age, and it is associated with chronic pelvic pain, dyspareunia and infertility. As a …
[HTML][HTML] Ethiopathogenic mechanisms of endometriosis-related infertility
Endometriosis is a highly prevalent disease among women of reproductive age and is
frequently associated to infertility. However, the mechanisms underlying endometriosis …
frequently associated to infertility. However, the mechanisms underlying endometriosis …
Single-cell RNA sequencing of oocytes from ovarian endometriosis patients reveals a differential transcriptomic profile associated with lower quality
H Ferrero, A Corachán, A Aguilar… - Human …, 2019 - academic.oup.com
STUDY QUESTION Do oocytes from women with ovarian endometriosis (OE) have a
different transcriptomic profile than those from healthy women? SUMMARY ANSWER …
different transcriptomic profile than those from healthy women? SUMMARY ANSWER …
Redox biology of human cumulus cells: basic concepts, impact on oocyte quality, and potential clinical use
L von Mengden, F Klamt, J Smitz - Antioxidants & redox signaling, 2020 - liebertpub.com
Significance: Four decades have passed since the first successful human embryo conceived
from a fertilization in vitro. Despite all advances, success rates in assisted reproduction …
from a fertilization in vitro. Despite all advances, success rates in assisted reproduction …
Decreased oocyte quality in patients with endometriosis is closely related to abnormal granulosa cells
W Fan, Z Yuan, M Li, Y Zhang, F Nan - Frontiers in Endocrinology, 2023 - frontiersin.org
Infertility and menstrual abnormalities in endometriosis patients are frequently caused by
aberrant follicular growth or a reduced ovarian reserve. Endometriosis typically does not …
aberrant follicular growth or a reduced ovarian reserve. Endometriosis typically does not …
Current understanding of and future directions for endometriosis-related infertility research with a focus on ferroptosis
H Kobayashi, C Yoshimoto, S Matsubara, H Shigetomi… - Diagnostics, 2023 - mdpi.com
Background: To date, the development of therapy for endometriosis and disease-related
infertility remains a major challenge. Iron overload caused by periodic bleeding is a hallmark …
infertility remains a major challenge. Iron overload caused by periodic bleeding is a hallmark …
Single-cell analysis of differences in transcriptomic profiles of oocytes and cumulus cells at GV, MI, MII stages from PCOS patients
Q Liu, Y Li, Y Feng, C Liu, J Ma, Y Li, H Xiang, Y Ji… - Scientific reports, 2016 - nature.com
Polycystic ovary syndrome (PCOS) is a common frequent endocrine disorder among women
of reproductive age. Although assisted reproductive techniques (ARTs) are used to address …
of reproductive age. Although assisted reproductive techniques (ARTs) are used to address …
Transcriptomic analysis of cumulus cells shows altered pathways in patients with minimal and mild endometriosis
CM Da Luz, MG Da Broi, LO Koopman, JR Plaça… - Scientific Reports, 2022 - nature.com
Endometriosis is a chronic inflammatory disorder that is highly associated with infertility. This
association seems to be related to oocyte impairment, mainly in the initial stages of …
association seems to be related to oocyte impairment, mainly in the initial stages of …
Obesity-dependent increases in oocyte mRNAs are associated with increases in proinflammatory signaling and gut microbial abundance of Lachnospiraceae in …
F Xie, CL Anderson, KR Timme, SG Kurz… - …, 2016 - academic.oup.com
RNAs stored in the metaphase II-arrested oocyte play important roles in successful
embryonic development. Their abundance is defined by transcriptional activity during oocyte …
embryonic development. Their abundance is defined by transcriptional activity during oocyte …