Large conductance Ca 2+-and voltage-activated K+(BK) channels are widely distributed in
the postnatal central nervous system (CNS). BK channels play a pleiotropic role in …

Animal studies have been instrumental in providing knowledge about the molecular and
neural mechanisms underlying drug addiction. Recently, the fruit fly Drosophila …

This review discusses evidence for and apparent controversy about, γ-aminobutyric acid
type A (GABAA) receptor (GABAAR) subtypes that mediate alcohol effects experienced …

Alcohol is a widely used and abused substance with numerous negative consequences for
human health and safety. Historically, alcohol's widespread, non-specific neurobiological …

Alcoholism is a complex psychiatric disorder that has a multifactorial etiology. Epigenetic
mechanisms are uniquely capable of accounting for the multifactorial nature of the disease …

Drosophila melanogaster has become a significant model organism for alcohol research. In
flies, a rich variety of behaviors can be leveraged for identifying genes affecting alcohol …

Addiction is a progressive and complex disease that encompasses a wide range of
disorders and symptoms, including substance use disorder (SUD), for which there are few …

Enhanced acute tolerance predicts alcohol abuse. We describe work on the role of the
calcium-and voltage-gated BK channel in alcohol tolerance, highlighting the lipid …

Background Alcoholism presents widespread social and human health problems. Alcohol
sensitivity, the development of tolerance to alcohol and susceptibility to addiction vary in the …

Alcohol abuse and alcoholism incur a heavy socioeconomic cost in many countries. Both
genetic and environmental factors contribute to variation in the inebriating effects of alcohol …