Abstract Purpose of Review Here, we discuss the origin of chondrocytes, their destiny, and
their plasticity in relationship to bone growth, articulation, and formation of the trabeculae …

Cartilage is essential throughout vertebrate life. It starts developing in embryos when
osteochondroprogenitor cells commit to chondrogenesis, activate a pancartilaginous …

Bone age (BA) is a clinical marker of bone maturation which indicates the developmental
stage of endochondral ossification at the epiphysis and the growth plate. Hormones that …

Disuse osteoporosis is characterized by decreased bone mass caused by abnormal
mechanical stimulation of bone. Piezo1 is a major mechanosensitive ion channel in bone …

The periodontal ligament (PDL) contains mesenchymal stem cells (MSCs) that can
differentiate into osteoblasts, cementoblasts, and fibroblasts. Nevertheless, the distribution …

Background/objectives Articular cartilage erosion probably plays a substantial role in
osteoarthritis (OA) initiation and development. Studies demonstrated that umbilical cord …

Meniscal tears are associated with a high risk of osteoarthritis but currently have no disease-
modifying therapies. Using a Gli1 reporter line, we found that Gli1+ cells contribute to the …

Bioactive materials harness the body's innate regenerative potential by directing
endogenous progenitor cells to facilitate tissue repair. Dissolution products of inorganic …

The hedgehog (Hh) signaling pathway plays an essential role in both tissue development
and homeostasis. Glioma‐associated oncogene homolog 1 (Gli1) is one of the vital …

Genetic mutations in the Xylt1 gene are associated with Desbuquois dysplasia type II
syndrome characterized by sever prenatal and postnatal short stature. However, the specific …