Metabolism by aldehyde oxidase: drug design and complementary approaches to challenges in drug discovery
N Manevski, L King, WR Pitt, F Lecomte… - Journal of Medicinal …, 2019 - ACS Publications
Aldehyde oxidase (AO) catalyzes oxidations of azaheterocycles and aldehydes, amide
hydrolysis, and diverse reductions. AO substrates are rare among marketed drugs, and …
hydrolysis, and diverse reductions. AO substrates are rare among marketed drugs, and …
Roles of selected non-P450 human oxidoreductase enzymes in protective and toxic effects of chemicals: review and compilation of reactions
SP Rendić, RD Crouch, FP Guengerich - Archives of Toxicology, 2022 - Springer
This is an overview of the metabolic reactions of drugs, natural products, physiological
compounds, and other (general) chemicals catalyzed by flavin monooxygenase (FMO) …
compounds, and other (general) chemicals catalyzed by flavin monooxygenase (FMO) …
Aldehyde oxidase contributes to all-trans-retinoic acid biosynthesis in human liver
G Zhong, CJ Seaman, EM Paragas, H Xi… - Drug Metabolism and …, 2021 - ASPET
All-trans-retinoic acid (at RA) is a critical endogenous signaling molecule. at RA is
predominantly synthesized from retinaldehyde by aldehyde dehydrogenase 1A1 …
predominantly synthesized from retinaldehyde by aldehyde dehydrogenase 1A1 …
Time course of aldehyde oxidase and why it is nonlinear
Many promising drug candidates metabolized by aldehyde oxidase (AOX) fail during clinical
trial owing to underestimation of their clearance. AOX is species-specific, which makes …
trial owing to underestimation of their clearance. AOX is species-specific, which makes …
Aldehyde oxidase at the crossroad of metabolism and preclinical screening
Human AOX1 is a member of the mammalian aldehyde oxidase (AOX) family of enzymes
and it is an emerging cytosolic enzyme involved in phase I drug-metabolism, bio …
and it is an emerging cytosolic enzyme involved in phase I drug-metabolism, bio …
Site-directed mutagenesis at the molybdenum pterin cofactor site of the human aldehyde oxidase: Interrogating the kinetic differences between human and …
The estimation of the drug clearance by aldehyde oxidase (AO) has been complicated
because of this enzyme's atypical kinetics and species and substrate specificity. Since …
because of this enzyme's atypical kinetics and species and substrate specificity. Since …
Production of active recombinant human aldehyde oxidase (AOX) in the baculovirus expression vector system (BEVS) and deployment in a pre-clinical fraction-of …
Human aldehyde oxidase (AOX) has emerged as a key enzyme activity for consideration in
modern drug discovery. The enzyme catalyzes the oxidation of a wide variety of compounds …
modern drug discovery. The enzyme catalyzes the oxidation of a wide variety of compounds …
Enzyme Kinetics, Pharmacokinetics, and Inhibition of Aldehyde Oxidase
Aldehyde oxidase (AO) has emerged as an important drug metabolizing enzyme over the
last decade. Several compounds have failed in the clinic because the clearance or toxicity …
last decade. Several compounds have failed in the clinic because the clearance or toxicity …
[PDF][PDF] Site Directed Mutagenesis at the MoCo Site of the Human Aldehyde Oxidase: Interrogating the Kinetic Differences Between Human and Cynomolgus Monkey
A Abbasi, CA Joswig-Jones… - Drug Metabolism and …, 2020 - researchgate.net
The estimation of the drug clearance by aldehyde oxidase (AO) has been complicated
because of this enzyme's atypical kinetics and species and substrate specificity. Since …
because of this enzyme's atypical kinetics and species and substrate specificity. Since …
Bile Salt Export Pump (BSEP) Inhibition
A Treiber, MH Bolli - 2021 - books.rsc.org
The bile salt export pump BSEP (in humans)/Bsep (in animals) is a member of the ATP-
binding cassette (ABC) superfamily of transport proteins. Its systematic name is ABCB11 …
binding cassette (ABC) superfamily of transport proteins. Its systematic name is ABCB11 …