Recent Advances and Future Directions on Small Molecule VEGFR Inhibitors in Oncological Conditions
A Thakur, M Rana, A Mishra, C Kaur, CH Pan… - European Journal of …, 2024 - Elsevier
ABSTRACT “A journey of mixed emotions” is a quote that best describes the progress chart
of vascular endothelial growth factor receptor (VEGFR) inhibitors as cancer therapeutics in …
of vascular endothelial growth factor receptor (VEGFR) inhibitors as cancer therapeutics in …
Ferroptosis and oral squamous cell carcinoma: connecting the dots to move forward
A Antonelli, AM Battaglia, A Sacco, L Petriaggi… - Frontiers in Oral …, 2024 - frontiersin.org
Oral squamous cell carcinoma (OSCC) is an aggressive disease whose incomplete
biological comprehension contributes to the inappropriate clinical management and poor …
biological comprehension contributes to the inappropriate clinical management and poor …
The β2-adrenergic receptor associates with CXCR4 multimers in human cancer cells
J Liang, M Seghiri, PK Singh, HG Seo… - Proceedings of the …, 2024 - National Acad Sciences
While the existence and functional role of class C G-protein-coupled receptors (GPCR)
dimers is well established, there is still a lack of consensus regarding class A and B GPCR …
dimers is well established, there is still a lack of consensus regarding class A and B GPCR …
Expression of PTGS2 along with genes regulating VEGF signalling pathway and association with high‐risk factors in locally advanced oral squamous cell carcinoma
Abstract Background PTGS2 encodes cyclooxygenase‐2 (COX‐2), which catalyses the
committed step in prostaglandin synthesis. Various in vivo and in vitro data suggest that …
committed step in prostaglandin synthesis. Various in vivo and in vitro data suggest that …
Deciphering the complex landscape of post-translational modifications on PKM2: Implications in head and neck cancer pathogenesis
In the vast landscape of human health, head and neck cancer (HNC) poses a significant
health burden globally, necessitating the exploration of novel diagnostics and therapeutics …
health burden globally, necessitating the exploration of novel diagnostics and therapeutics …
Magnesium-related gene ITGAL: a key immunotherapy predictor and prognostic biomarker in pan-cancer
F Lin, H Yang, Z Huang, Y Li, Q Ding, Y Ye… - Frontiers in …, 2024 - frontiersin.org
Background Integrin subunit alpha L (ITGAL) is crucial for activating CD8+ T cells through
magnesium-mediated immune synapse formation and specific cytotoxicity. ITGAL might …
magnesium-mediated immune synapse formation and specific cytotoxicity. ITGAL might …
Antiapoptotic PON2 expression and its clinical implications in locally advanced oral squamous cell carcinoma
Locally advanced oral squamous cell carcinoma poses a significant challenge in oncology
due to its rising incidence and mortality rates. Despite therapeutic progress, understanding …
due to its rising incidence and mortality rates. Despite therapeutic progress, understanding …
Logistic PCA explains differences between genome-scale metabolic models in terms of metabolic pathways
L Zehetner, D Széliová, B Kraus… - PLOS Computational …, 2024 - journals.plos.org
Genome-scale metabolic models (GSMMs) offer a holistic view of biochemical reaction
networks, enabling in-depth analyses of metabolism across species and tissues in multiple …
networks, enabling in-depth analyses of metabolism across species and tissues in multiple …
Molecular and Histopathological Characterization of Metastatic Cutaneous Squamous Cell Carcinomas: A Case–Control Study
A Paganelli, M Zaffonato, B Donati, F Torricelli… - Cancers, 2024 - mdpi.com
Simple Summary This study investigates the characteristics of metastatic cutaneous
squamous cell carcinoma (cSCC) to improve patient risk stratification. By comparing patients …
squamous cell carcinoma (cSCC) to improve patient risk stratification. By comparing patients …
Identification of key genes and pathways involved in T-DM1-resistance in OE-19 esophageal cancer cells through bioinformatics analysis
F Yazdani, N Mottaghi-Dastjerdi, B Shahbazi… - Heliyon, 2024 - cell.com
Abstract Introduction Esophageal Cancer (EC) ranks among the most common malignancies
worldwide. Most EC patients acquire drug resistance to chemotherapy either intrinsically or …
worldwide. Most EC patients acquire drug resistance to chemotherapy either intrinsically or …