Structure-based discovery of small molecules that disaggregate Alzheimer's disease tissue derived tau fibrils in vitro

PM Seidler, KA Murray, DR Boyer, P Ge… - Nature …, 2022 - nature.com
Alzheimer's disease (AD) is the consequence of neuronal death and brain atrophy
associated with the aggregation of protein tau into fibrils. Thus disaggregation of tau fibrils …

Tau; one protein, so many diseases

P Tabeshmehr, E Eftekharpour - Biology, 2023 - mdpi.com
Simple Summary Tau is an important protein for maintaining the shape and normal function
of nerve cells. There are many diseases that are identified by changes in this protein, yet …

Initiation and modulation of Tau protein phase separation by the drug suramin

PR Prince, J Hochmair, H Brognaro, S Gevorgyan… - Scientific Reports, 2023 - nature.com
Tau is an intrinsically disordered neuronal protein in the central nervous system. Aggregated
Tau is the main component of neurofibrillary tangles observed in Alzheimer's disease. In …

(−)-Epigallocatechin-3-gallate, a Polyphenol from Green Tea, Regulates the Liquid–Liquid Phase Separation of Alzheimer's-Related Protein Tau

J Chen, W Ma, J Yu, X Wang, H Qian, P Li… - Journal of Agricultural …, 2023 - ACS Publications
The microtubule-associated protein tau is involved in Alzheimer's disease and other
tauopathies. Recently, tau has been shown to undergo liquid–liquid phase separation …

Tau-aggregation inhibition: promising role of nanoencapsulated dietary molecules in the management of Alzheimer's disease

PG Nagaraju, P Priyadarshini - Critical Reviews in Food Science …, 2023 - Taylor & Francis
Alzheimer's disease (AD) is a cumulative form of dementia associated with memory loss,
cognition impairment, and finally leading to death. AD is characterized by abnormal deposits …

Study of EGCG composite hydrogel for the treatment of radiation-induced skin injuries

J Wang, L Gao, J Song, S Li - Journal of Applied Biomaterials …, 2023 - journals.sagepub.com
With the rising incidence of cancer, radiotherapy has become an increasingly popular
treatment modality. However, radiation-induced skin injuries (RSIs) have emerged as a …

Microglial Uptake of Extracellular Tau by Actin-Mediated Phagocytosis

H Chidambaram, SE Desale, T Qureshi… - … : Method and Protocols, 2024 - Springer
Microglia are scavengers of the brain environment that clear dead cells, debris, and
microbes. In Alzheimer's disease, microglia get activated to phagocytose damaged neurons …

On the contribution of Tau phosphorylation to nuclear and cytoplasmic changes in human neuroblastoma cells

P Tabeshmehr - 2023 - mspace.lib.umanitoba.ca
Human tauopathies are characterized by intracellular aggregation of hyperphosphorylated
tau protein in neurons. Tau is involved in many cellular functions through its association with …

[引用][C] Nuclear Tau accumulation in Alzheimer's disease

S Chinnathambi, G Velmurugan, S Suresh, A Adithyan… - 2024 - Elsevier