Serpins are a superfamily of proteins, whose membership is based on the presence of a
single common core domain consisting of three β-sheets and 8-9 R-helices, and with a set of …

Clinical observations and accumulating laboratory evidence support a complex interplay
between coagulation, inflammation, innate immunity and fibrinolysis in venous …

T HE PLASMINOGEN activator (PA) system is responsi-ble for the degradation of
intravascular blood clots,'while also contributing to extracellular proteolysis in a wide variety …

Point mutations cause members of the serine protease inhibitor (serpin) superfamily to
undergo a novel conformational transition, forming ordered polymers. These polymers …

Introduction: The urokinase plasminogen activator (uPA) system, comprising the serine
protease uPA, its cognate receptor, uPAR, and two endogenous inhibitors, plasminogen …

The plasmin–antiplasmin system plays a key role in blood coagulation and fibrinolysis.
Plasmin and α 2-antiplasmin are primarily responsible for a controlled and regulated …

Currently, there are several studies supporting the role of urokinase‐type plasminogen
activator (uPA) system in cancer. The association of uPA to its receptor triggers the …

BACKGROUND Extravillous trophoblast (EVT) cell invasion of uterine decidua and the inner
third of myometrium is critical for successful pregnancy. Many decidual factors are likely to …

Tumour expression of the urokinase plasminogen activator correlates with invasive capacity.
Consequently, inhibition of this serine protease by physiological inhibitors should decrease …

The effectiveness of fibrinolysis results from the combination of regulated enzymatic activity
and the physical properties of the fibrin scaffold. Physiologically, clots or thrombi are …