Protein aggregation is the main hallmark of neurodegenerative diseases. Many proteins
found in pathological inclusions are known to undergo liquid-liquid phase separation, a …

TAR DNA binding protein 43 (TDP-43) is a versatile RNA/DNA binding protein involved in
RNA-related metabolism. Hyper-phosphorylated and ubiquitinated TDP-43 deposits act as …

Amyotrophic lateral sclerosis (ALS) is an intractable disease that causes respiratory failure
leading to mortality. The main locus of ALS is motor neurons. The success of antisense …

Abstract TAR DNA-binding protein 43 (TDP-43) is a highly conserved nuclear RNA/DNA-
binding protein involved in the regulation of RNA processing. The accumulation of TDP-43 …

TAR DNA binding protein 43 (TDP-43) is a DNA/RNA binding protein involved in pivotal
cellular functions, especially in RNA metabolism. Hyperphosphorylated and ubiquitinated …

MicroRNAs (miRNAs) are 22-nucleotide noncoding RNAs involved in the differentiation,
development, and function of cells in the body by targeting the 3′-untranslated regions …

TAR DNA binding protein of 43 kDa (TDP-43)-positive inclusions in neurons are a hallmark
of several neurodegenerative diseases including familial amyotrophic lateral sclerosis …

Background and objectives Genetic variants in the gene TARDBP, encoding TDP‐43
protein, are associated with amyotrophic lateral sclerosis (ALS) in familial (fALS) and …

TDP-43 is an RNA-binding protein that has been robustly linked to the pathogenesis of a
number of neurodegenerative disorders, including amyotrophic lateral sclerosis and …

Genetic abnormalities play a crucial role in the development of neurodegenerative disorders
(NDDs). Genetic exploration has indeed contributed to unraveling the molecular …