The T-box family of transcription factors exhibits widespread involvement throughout
development in all metazoans. T-box proteins are characterized by a DNA-binding motif …

Background An impressive percentage of biomedical advances were achieved through
animal research and cell culture investigations. For drug testing and disease researches …

We present WhichTF, a computational method to identify functionally important transcription
factors (TFs) from chromatin accessibility measurements. To rank TFs, WhichTF applies an …

In mammals, specification of the three major germ layers occurs during gastrulation, when
cells ingressing through the primitive streak differentiate into the precursor cells of major …

Cell fate specification relies on the action of critical transcription factors that become
available at distinct stages of embryonic development. One such factor is NeuroD1, which is …

Objective The generation of acinar and ductal cells from human pluripotent stem cells
(PSCs) is a poorly studied process, although various diseases arise from this compartment …

To harness the potential of human pluripotent stem cells (hPSCs), an abundant supply of
their progenies is required. Here, hPSC expansion as matrix-independent aggregates in …

Pancreatic ductal adenocarcinoma (PDAC) is associated with accumulation of particular
oncogenic mutations and recent genetic sequencing studies have identified ataxia …

For a long time, it has been assumed that the only role of sperm at fertilization is to introduce
the male genome into the egg. Recently, ideas have emerged that the epigenetic state of the …

Objective Cancer stem cells (CSCs) represent the root of many solid cancers including
pancreatic ductal adenocarcinoma, are highly chemoresistant and represent the cellular …