DNA microarrays have allowed us to monitor the effects of pathogens on host-cell gene
expression programmes in great depth and on a broad scale. The comparison of results that …

Progranulin (Pgrn) is a pluripotent secreted growth factor that mediates cell cycle
progression and cell motility. It activates the extracellular regulated kinases and …

Microglia constitute the primary resident immune surveillance cell in the brain and are
thought to play a significant role in the pathogenesis of several neurodegenerative …

To study the capacity of human neurons to mount innate immunity responses to viral
infections, we infected cells of a human postmitotic neuron-derivative cell line, NT2-N, with …

Due to its channel-like properties, the peripheral-type benzodiazepine receptor (PBR) has
been renamed the translocator protein (TSPO). In eukaryotes, the TSPO is primarily located …

The innate immune response, and in particular the alpha/beta interferon (IFN-α/β) system,
plays a critical role in the control of viral infections. Interferons α and β exert their antiviral …

Alphaviruses productively infect a variety of vertebrate and insect cell lines. In vertebrate
cells, Sindbis virus redirects cellular processes to meet the needs of virus propagation. At …

Though the interferon-inducible protein ISG15 was one of the first ubiquitin-like modifiers to
be discovered, much remains unknown about the identity of proteins conjugated to ISG15 or …

Progranulin (PGRN) is a pleiotropic protein that has gained the attention of the neuroscience
community with recent discoveries of mutations in the gene for PGRN that cause …

Apoptosis is associated with virus-induced human diseases of the central nervous system,
heart and liver, and causes substantial morbidity and mortality. Although virus-induced …