Insights into host responses against pathogens from transcriptional profiling
DNA microarrays have allowed us to monitor the effects of pathogens on host-cell gene
expression programmes in great depth and on a broad scale. The comparison of results that …
expression programmes in great depth and on a broad scale. The comparison of results that …
Progranulin (granulin-epithelin precursor, PC-cell-derived growth factor, acrogranin) mediates tissue repair and tumorigenesis
Z He, A Bateman - Journal of molecular medicine, 2003 - Springer
Progranulin (Pgrn) is a pluripotent secreted growth factor that mediates cell cycle
progression and cell motility. It activates the extracellular regulated kinases and …
progression and cell motility. It activates the extracellular regulated kinases and …
The peripheral benzodiazepine receptor (translocator protein 18 kDa) in microglia: from pathology to imaging
S Venneti, BJ Lopresti, CA Wiley - Progress in neurobiology, 2006 - Elsevier
Microglia constitute the primary resident immune surveillance cell in the brain and are
thought to play a significant role in the pathogenesis of several neurodegenerative …
thought to play a significant role in the pathogenesis of several neurodegenerative …
Virus infection switches TLR-3-positive human neurons to become strong producers of beta interferon
C Préhaud, F Mégret, M Lafage, M Lafon - Journal of virology, 2005 - Am Soc Microbiol
To study the capacity of human neurons to mount innate immunity responses to viral
infections, we infected cells of a human postmitotic neuron-derivative cell line, NT2-N, with …
infections, we infected cells of a human postmitotic neuron-derivative cell line, NT2-N, with …
Channel-like functions of the 18-kDa translocator protein (TSPO): regulation of apoptosis and steroidogenesis as part of the host-defense response
L Veenman, V Papadopoulos… - Current pharmaceutical …, 2007 - ingentaconnect.com
Due to its channel-like properties, the peripheral-type benzodiazepine receptor (PBR) has
been renamed the translocator protein (TSPO). In eukaryotes, the TSPO is primarily located …
been renamed the translocator protein (TSPO). In eukaryotes, the TSPO is primarily located …
Identification of interferon-stimulated gene 15 as an antiviral molecule during Sindbis virus infection in vivo
DJ Lenschow, NV Giannakopoulos, LJ Gunn… - Journal of …, 2005 - Am Soc Microbiol
The innate immune response, and in particular the alpha/beta interferon (IFN-α/β) system,
plays a critical role in the control of viral infections. Interferons α and β exert their antiviral …
plays a critical role in the control of viral infections. Interferons α and β exert their antiviral …
Roles of nonstructural protein nsP2 and alpha/beta interferons in determining the outcome of Sindbis virus infection
EI Frolova, RZ Fayzulin, SH Cook, DE Griffin… - Journal of …, 2002 - Am Soc Microbiol
Alphaviruses productively infect a variety of vertebrate and insect cell lines. In vertebrate
cells, Sindbis virus redirects cellular processes to meet the needs of virus propagation. At …
cells, Sindbis virus redirects cellular processes to meet the needs of virus propagation. At …
Proteomic identification of proteins conjugated to ISG15 in mouse and human cells
NV Giannakopoulos, JK Luo, V Papov, W Zou… - Biochemical and …, 2005 - Elsevier
Though the interferon-inducible protein ISG15 was one of the first ubiquitin-like modifiers to
be discovered, much remains unknown about the identity of proteins conjugated to ISG15 or …
be discovered, much remains unknown about the identity of proteins conjugated to ISG15 or …
Progranulin in frontotemporal lobar degeneration and neuroinflammation
Z Ahmed, IRA Mackenzie, ML Hutton… - Journal of …, 2007 - Springer
Progranulin (PGRN) is a pleiotropic protein that has gained the attention of the neuroscience
community with recent discoveries of mutations in the gene for PGRN that cause …
community with recent discoveries of mutations in the gene for PGRN that cause …
Apoptosis in animal models of virus-induced disease
P Clarke, KL Tyler - Nature Reviews Microbiology, 2009 - nature.com
Apoptosis is associated with virus-induced human diseases of the central nervous system,
heart and liver, and causes substantial morbidity and mortality. Although virus-induced …
heart and liver, and causes substantial morbidity and mortality. Although virus-induced …