TP53, a crucial tumor suppressor gene, is the most commonly mutated gene in human
cancers. Aside from losing its tumor suppressor function, mutant p53 (mutp53) often …

In this review we focus on the major isoforms of the tumor-suppressor protein p53,
dysfunction of which often leads to cancer. Mutations of the TP53 gene, particularly in the …

The transcription factor, p53, is critical for many important cellular functions involved in
genome integrity, including cell cycle control, DNA damage response, and apoptosis …

Similar to neurodegenerative diseases, the concept that tumors are prion like diseases has
been proposed in recent years. p53, the most well-known tumor suppressor, has been …

Eukaryotic cells are intracellularly divided into numerous compartments or organelles, which
coordinate specific molecules and biological reactions. Membrane‐bound organelles are …

Mutant p53 tends to form aggregates with amyloid properties, especially amyloid oligomers
inside the nucleus, which are believed to cause oncogenic gain-of-function (GoF). The …

The p53 protein plays a critical role in the prevention of genome mutations in the body,
however, this protein is frequently mutated in cancer and almost all cancers exhibit …

The transcriptional regulator p53 has an essential role in tumor suppression. Almost 50% of
human cancers are associated with the loss of p53 functions, where p53 often accumulates …

Conspectus Prion-like behavior of several amyloidogenic proteins has been demonstrated
in recent years. Despite having functional roles in some cases, irregular aggregation can …

p53 mutants can form amyloid-like structures that accumulate in cells. p53 reactivation with
induction of massive apoptosis-1 (PRIMA-1) and its primary active metabolite, 2-methylene …