The elusive cephalic phase insulin response: triggers, mechanisms, and functions
W Langhans, AG Watts, AC Spector - Physiological reviews, 2023 - journals.physiology.org
The cephalic phase insulin response (CPIR) is classically defined as a head receptor-
induced early release of insulin during eating that precedes a postabsorptive rise in blood …
induced early release of insulin during eating that precedes a postabsorptive rise in blood …
Measurement of pulsatile insulin secretion: Rationale and methodology
MC Laurenti, A Matveyenko, A Vella - Metabolites, 2021 - mdpi.com
Pancreatic β-cells are responsible for the synthesis and exocytosis of insulin in response to
an increase in circulating glucose. Insulin secretion occurs in a pulsatile manner, with …
an increase in circulating glucose. Insulin secretion occurs in a pulsatile manner, with …
[HTML][HTML] Diabetes-associated genetic variation in TCF7L2 alters pulsatile insulin secretion in humans
MC Laurenti, C Dalla Man, RT Varghese, JC Andrews… - JCI insight, 2020 - ncbi.nlm.nih.gov
BACKGROUND Metabolic disorders such as type 2 diabetes have been associated with a
decrease in insulin pulse frequency and amplitude. We hypothesized that the T allele at …
decrease in insulin pulse frequency and amplitude. We hypothesized that the T allele at …
The relationship between insulin and glucagon concentrations in non‐diabetic humans
MC Laurenti, P Arora, C Dalla Man… - Physiological …, 2022 - Wiley Online Library
Abnormal postprandial suppression of glucagon in Type 2 diabetes (T2DM) has been
attributed to impaired insulin secretion. Prior work suggests that insulin and glucagon show …
attributed to impaired insulin secretion. Prior work suggests that insulin and glucagon show …
Insulin pulse characteristics and insulin action in non-diabetic humans
MC Laurenti, C Dalla Man, RT Varghese… - The Journal of …, 2021 - academic.oup.com
Objective Pulsatile insulin secretion is impaired in diseases such as type 2 diabetes that are
characterized by insulin resistance. This has led to the suggestion that changes in insulin …
characterized by insulin resistance. This has led to the suggestion that changes in insulin …
Islet Hormone Secretion, Action and Interaction in Health and Disease
MC Laurenti - 2022 - search.proquest.com
Type 2 diabetes mellitus (T2DM) is a metabolic disease characterized by a dysregulation of
glucose homeostasis. The pathophysiology of this disease is complex characterized by a …
glucose homeostasis. The pathophysiology of this disease is complex characterized by a …
[引用][C] To determine the effect of endogenous GLP-1 secretion on islet function in people with and without Type 2 Diabetes
A Vella - IRB