The chemokine ligand CCL2 and its receptor CCR2 are implicated in the initiation and
progression of various cancers. CCL2 can activate tumour cell growth and proliferation …

Chemokines are a family of small cytokines, which guide a variety of immune/inflammatory
cells to the site of tumor in tumorigenesis. A dysregulated expression of chemokines is …

CCR2 is predominantly expressed by monocytes/macrophages with strong proinflammatory
functions, prompting the development of CCR2 antagonists to dampen unwanted immune …

Chemokine receptors comprise a large family of seven transmembrane domain G protein-
coupled receptors differentially expressed in diverse cell types. Biological activities have …

T helper cells type 1 (Th1s) that produce interferon-γ predominantly mediate cellular
immune responses and are involved in the development of chronic inflammatory conditions …

DCs (dendritic cells) function as sentinels of the immune system. They traffic from the blood
to the tissues where, while immature, they capture antigens. They then leave the tissues and …

Members of the Toll-like receptor (TLR) family probably play a fundamental role in pathogen
recognition and activation of innate immunity. The present study used a systematic approach …

Dendritic cells (DC) migrate into inflamed peripheral tissues where they capture antigens
and, following maturation, to lymph nodes where they stimulate T cells. To gain insight into …

Dendritic cells (DCs) are critical for adaptive immunity and tolerance. Most DCs are
strategically positioned as immune sentinels poised to respond to invading pathogens in …

Chemokines are a family of low molecular weight proteins with an essential role in leukocyte
trafficking during both homeostasis and inflammation. The CC class of chemokines consists …