Etiology, transmission and protection: Chlamydia trachomatis is the leading cause of
bacterial sexually transmitted infection (STI) globally. However, C. trachomatis also causes …

Antibodies are now recognized as key therapeutic tools to combat most forms of malignancy.
Although the first wave of therapeutic antibodies that emerged over two decades ago directly …

Subcapsular sinus (SCS) macrophages capture antigens from lymph and present them
intact for B cell encounter and follicular delivery. However, the properties of SCS …

Most patients with COVID-19 lack antibody to SARS-CoV-2 in the first 10 days of illness
while the virus drives disease pathogenesis. SARS-CoV-2 antibody deficiency in the setting …

Acquired immunity to murine Chlamydia trachomatis genital tract reinfection has long been
assumed to be solely dependent on cell-mediated immunity. However, in this study, we …

Half a century after the introduction of Amphotericin B the management of cryptococcosis
remains unsatisfactory. The disease, caused primarily by the two fungal species …

We have previously demonstrated that B cells can shape the immune response to
Mycobacterium tuberculosis, including the level of neutrophil infiltration and granulomatous …

The immune response involves a complex repertoire of innate and adaptive responses to
foreign agents in the organism. The present review focuses on the immune response to …

Differentiation of naïve B cells, including immunoglobulin class-switch DNA recombination,
is critical for the immune response and depends on the extensive integration of signals from …

Sometime in the mid to late twentieth century the study of antibody‐mediated immunity (AMI)
entered the doldrums, as many immunologists believed that the function of AMI was well …