Outer hair cells and electromotility
J Ashmore - Cold Spring Harbor perspectives in …, 2019 - perspectivesinmedicine.cshlp.org
Outer hair cells (OHCs) of the mammalian cochlea behave like actuators: they feed energy
into the cochlear partition and determine the overall mechanics of hearing. They do this by …
into the cochlear partition and determine the overall mechanics of hearing. They do this by …
Structural determinants of protocadherin-15 mechanics and function in hearing and balance perception
D Choudhary, Y Narui, BL Neel… - Proceedings of the …, 2020 - National Acad Sciences
The vertebrate inner ear, responsible for hearing and balance, is able to sense minute
mechanical stimuli originating from an extraordinarily broad range of sound frequencies and …
mechanical stimuli originating from an extraordinarily broad range of sound frequencies and …
Multiscale modeling of mechanotransduction in the utricle
JH Nam, JW Grant, MH Rowe… - Journal of …, 2019 - journals.physiology.org
We review recent progress in using numerical models to relate utricular hair bundle and
otoconial membrane (OM) structure to the functional requirements imposed by natural …
otoconial membrane (OM) structure to the functional requirements imposed by natural …
A mechanically weak extracellular membrane-adjacent domain induces dimerization of protocadherin-15
The cadherin superfamily of proteins is defined by the presence of extracellular cadherin
(EC)" repeats" that engage in protein-protein interactions to mediate cell-cell adhesion, cell …
(EC)" repeats" that engage in protein-protein interactions to mediate cell-cell adhesion, cell …
Phase locking of auditory nerve fibers: the role of lowpass filtering by hair cells
AJ Peterson, P Heil - Journal of Neuroscience, 2020 - Soc Neuroscience
Phase locking of auditory-nerve-fiber (ANF) responses to the temporal fine structure of
acoustic stimuli, a hallmark of the auditory system's temporal precision, is important for many …
acoustic stimuli, a hallmark of the auditory system's temporal precision, is important for many …
Dimensions of a living cochlear hair bundle
KK Miller, P Atkinson, KR Mendoza… - Frontiers in Cell and …, 2021 - frontiersin.org
The hair bundle is the mechanosensory organelle of hair cells that detects mechanical
stimuli caused by sounds, head motions, and fluid flows. Each hair bundle is an assembly of …
stimuli caused by sounds, head motions, and fluid flows. Each hair bundle is an assembly of …
Phase locking of auditory-nerve fibers reveals stereotyped distortions and an exponential transfer function with a level-dependent slope
AJ Peterson, P Heil - Journal of Neuroscience, 2019 - Soc Neuroscience
Phase locking of auditory-nerve-fiber (ANF) responses to the fine structure of acoustic stimuli
is a hallmark of the auditory system's temporal precision and is important for many aspects of …
is a hallmark of the auditory system's temporal precision and is important for many aspects of …
Outer hair cell electromechanics as a problem in soft matter physics: Prestin, the membrane and the cytoskeleton
RM Raphael - Hearing Research, 2022 - Elsevier
The electromechanical coupling exhibited by cochlear outer hair cells is a remarkable
biophysical phenomenon. These specialized cells generate forces at acoustic frequencies …
biophysical phenomenon. These specialized cells generate forces at acoustic frequencies …
Coupling between the stereocilia of rat sensory inner-hair-cell hair bundles is weak, shaping their sensitivity to stimulation
The hair bundle is the universal mechanosensory organelle of auditory, vestibular, and
lateral-line systems. A bundle comprises mechanically coupled stereocilia, whose …
lateral-line systems. A bundle comprises mechanically coupled stereocilia, whose …
3D morphology of an outer-hair-cell hair bundle increases its displacement and dynamic range
In mammals, outer-hair-cell hair bundles (OHBs) transduce sound-induced forces into
receptor currents and are required for the wide dynamic range and high sensitivity of …
receptor currents and are required for the wide dynamic range and high sensitivity of …