Metformin as an emerging concern in wastewater: Occurrence, analysis and treatment methods

A Balakrishnan, M Sillanpää, MM Jacob… - Environmental Research, 2022 - Elsevier
Metformin is a wonder drug used as an anti-hypoglycemic medication; it is also used as a
cancer suppression medicament. Metformin is a first line of drug choice used by doctors for …

Chiral monolithic silica-based HPLC columns for enantiomeric separation and determination: functionalization of chiral selector and recognition of selector-selectand …

M Asmari, X Wang, N Casado, M Piponski… - Molecules, 2021 - mdpi.com
This review draws attention to the use of chiral monolithic silica HPLC columns for the
enantiomeric separation and determination of chiral compounds. Properties and advantages …

Experimental design methodology for optimization and robustness determination in ion pair RP-HPLC method development: Application for the simultaneous …

MA Mahrouse, NT Lamie - Microchemical Journal, 2019 - Elsevier
Experimental design methodology (DOE) surpasses traditional (one variable at a time)
approach in improving the chromatographic separation performance with minimum effort …

A validated LC-MS/MS method for simultaneous determination of linagliptin and metformin in spiked human plasma coupled with solid phase extraction: application to …

BA Moussa, MA Mahrouse, MG Fawzy - Journal of pharmaceutical and …, 2019 - Elsevier
Combination therapy has a pivotal role in type II diabetes mellitus management in patients
unable to maintain normal glycemic level using metformin alone. Addition of linagliptin …

Development and validation of rapid RP-HPLC and green second-derivative UV spectroscopic methods for simultaneous quantification of metformin and remogliflozin …

M Attimarad, REE Elgorashe, R Subramaniam… - Separations, 2020 - mdpi.com
Recently, a new formulation containing metformin HCl (MFH) and remogliflozin etabonate
(RGE) has been approved for the management of diabetes mellitus. However, only one …

Development and validation of green UV derivative spectrophotometric methods for simultaneous determination metformin and remogliflozin from formulation …

M Attimarad, AB Nair, N Sreeharsha… - International journal of …, 2021 - mdpi.com
The recent trend in green analytical chemistry is the development of green analytical
methods using environmentally friendly solvents. Therefore, three ecofriendly manipulated …

Determination of metformin bio-distribution by LC-MS/MS in mice treated with a clinically relevant paradigm

K Chaudhari, J Wang, Y Xu, A Winters, L Wang… - PLoS …, 2020 - journals.plos.org
Metformin, an anti-diabetes drug, has been recently emerging as a potential “anti-aging”
intervention based on its reported beneficial actions against aging in preclinical studies …

Application of experimental design in HPLC method optimization and robustness for the simultaneous determination of canagliflozin, empagliflozin, linagliptin, and …

BA Moussa, MA Mahrouse… - Biomedical …, 2021 - Wiley Online Library
Gliflozins and gliptins represent two different pharmacological drug classes that exert
different and potentially complementary glucose‐lowering effect in patients with type II …

A new strategy for the determination of the antidiabetics alogliptin, saxagliptin and vildagliptin using all-solid state potentiometric sensors

AR Derar, N Ahmed, EM Hussien - BMC chemistry, 2023 - Springer
Herein, we report on the development of disposable screen printed carbon, nanostructure
thin film Au/Pt and Pt/Pt all-solid state potentiometric sensors for some antidiabetic …

Mixed-mode solid phase extraction combined with LC-MS/MS for determination of empagliflozin and linagliptin in human plasma

PA Shah, PS Shrivastav, A George - Microchemical Journal, 2019 - Elsevier
A selective, sensitive, precise and accurate liquid chromatography-tandem mass
spectrometry method was developed and validated for the concurrent determination of …