Potassium ion homeostasis is essential for bacterial survival, playing roles in
osmoregulation, pH homeostasis, regulation of protein synthesis, enzyme activation …

Ion transport across cell membranes is essential to cell communication and signaling.
Passive ion transport is mediated by ion channels, membrane proteins that create ion …

The chloride-proton exchanger CLC-7 plays critical roles in lysosomal homeostasis and
bone regeneration and its mutation can lead to osteopetrosis, lysosomal storage disease …

A family of plant nuclear ion channels, including DMI1 (D oes not M ake I nfections 1) and its
homologs CASTOR and POLLUX, are required for the establishment of legume-microbe …

TrkH belongs to a superfamily of K+ transport proteins required for growth of bacteria in low
external K+ concentrations. The crystal structure of TrkH from Vibrio parahaemolyticus …

Mutations that modulate the activity of ion channels are essential tools to understand the
biophysical determinants that control their gating. Here, we reveal the conserved role played …

Cyclic di-AMP (c-di-AMP) is a relatively new member of the family of bacterial cyclic
dinucleotide second messengers. It has attracted significant attention in recent years …

Background Membrane proteins constitute a major group of proteins and are of great
significance as pharmaceutical targets, but underrepresented in the Protein Data Bank …

Mechanosensitive channels are ubiquitous and highly studied. However, the evolution of the
bacterial channels remains enigmatic. It can be argued that mechanosensitivity might be a …

RCK (regulating conductance of K+) domains are common regulatory domains that control
the activity of eukaryotic and prokaryotic K+ channels and transporters. In bacteria these …