Iron is essential for all living organisms. Many iron-containing proteins and metabolic
pathways play a key role in almost all cellular and physiological functions. The diversity of …

Summary Background The Millennium Declaration in 2000 brought special global attention
to HIV, tuberculosis, and malaria through the formulation of Millennium Development Goal …

Background Reliable and timely information on the leading causes of death in populations,
and how these are changing, is a crucial input into health policy debates. In the Global …

Estimating the changing burden of malaria disease remains difficult owing to limitations in
health reporting systems. Here, we use a transmission model incorporating acquisition and …

According to global annual estimates hunger/malnutrition is the major cause of death (36 of
62 million). Cardiovascular diseases and cancer (5.44 of 13.43 million) are the major causes …

Background Malaria transmission has recently fallen in many parts of Africa, but systematic
descriptions of infection and disease across all age groups are rare. Here, an …

Plasmodium vivax is the most prevalent human malaria parasite in the Americas. Previous
studies have contrasted the genetic diversity of parasite populations in the Americas with …

The relationship between community prevalence of Plasmodium falciparum and the burden
of severe, life-threatening disease remains poorly defined. To examine the three most …

Background Estimates of the burden of disease in adults in sub-Saharan Africa largely rely
on models of sparse data. We aimed to measure the burden of disease in adults living in a …

Background Although Odisha is the largest contributor to the malaria burden in India, no
systematic study has examined its malaria trends. Hence, the spatio-temporal trends in …