Meningitis is an inflammation of the meninges and subarachnoid space that can also involve
the brain cortex and parenchyma. It can be acquired spontaneously in the community …

The complement system is an essential player in innate and adaptive immunity. It consists of
three pathways (alternative, classical, and lectin) that initiate either spontaneously …

Despite considerable advances in the understanding of the pathogenesis of meningococcal
disease, this infection remains a major cause of morbidity and mortality globally. The role of …

The human complement system plays an important role in the defense against invading
pathogens, inflammation and homeostasis. Invading microbes, such as bacteria, directly …

Complement is an essential component of the immune system and human pathogenic
organisms have developed various mechanisms for evading complement mediated serum …

Neisseria gonorrhoeae causes the sexually transmitted infection gonorrhea, while Neisseria
meningitidis is an important cause of bacterial meningitis and sepsis. Complement is a …

The genus Burkholderia contains over 80 different Gram-negative species including both
plant and human pathogens, the latter of which can be classified into one of two groups: the …

Introduction Vaccines based on multiple antigens often induce an immune response, which
is higher than that triggered by each single component, with antibodies acting cooperatively …

Factor H binding protein (fHbp) is a lipoprotein of Neisseria meningitidis important for the
survival of the bacterium in human blood and a component of two recently licensed vaccines …

Developing efficacious vaccines for human malaria caused by Plasmodium falciparum is a
major global health priority, although this has proven to be immensely challenging over the …