Novel 3-(pyrazol-4-yl)-2-(1H-indole-3-carbonyl)acrylonitrile derivatives induce intrinsic and extrinsic apoptotic death mediated P53 in HCT116 colon carcinoma
MF Mohamed, NS Ibrahim, AA Saddiq… - Scientific Reports, 2023 - nature.com
A novel series of α-cyano indolylchalcones was prepared, and their chemical structures
were confirmed based on the different spectral data. Among them, compound 7f was …
were confirmed based on the different spectral data. Among them, compound 7f was …
[HTML][HTML] Natural products-isoxazole hybrids: A review of developments in medicinal chemistry
J Wang, DB Wang, LL Sui, T Luan - Arabian Journal of Chemistry, 2024 - Elsevier
Five-membered heterocycles containing nitrogen, oxygen atoms, especially isoxazoles, are
widely present in many natural products and drugs and have relevant medical and …
widely present in many natural products and drugs and have relevant medical and …
Novel thiazole-based cyanoacrylamide derivatives: DNA cleavage, DNA/BSA binding properties and their anticancer behaviour against colon and breast cancer cells
K Barakat, MA Ragheb, MH Soliman, AM Abdelmoniem… - BMC chemistry, 2024 - Springer
A novel series of 2-cyano-3-(pyrazol-4-yl)-N-(thiazol-2-yl) acrylamide derivatives (3a–f) were
synthesized using Knoevenagel condensation and characterized using various spectral …
synthesized using Knoevenagel condensation and characterized using various spectral …
Theoretical and molecular mechanistic investigations of novel (3-(furan-2-yl) pyrazol-4-yl) chalcones against lung carcinoma cell line (A549)
MF Mohamed, NS Ibrahim, AA Saddiq… - Naunyn-Schmiedeberg's …, 2023 - Springer
A new chalcone series has been developed that may be useful in the treatment of lung
cancer. The new series was confirmed by the different spectral tools. MTT assay was used to …
cancer. The new series was confirmed by the different spectral tools. MTT assay was used to …
Novel α-Cyano-Indolyl Chalcones as Anti-Cancer Candidates, Induce G1/S Cell Cycle Arrest and Sequentially Activate Caspases-7, 8, and 9 in Breast Carcinoma
AA Kashmiry, NS Ibrahim, MF Mohamed… - Polycyclic Aromatic …, 2024 - Taylor & Francis
Six substituted α-cyano-indolylchalcones have been prepared and their structures were
verified by various spectral analysis tools. Compared with the standard drug 5-Fluorouracil) …
verified by various spectral analysis tools. Compared with the standard drug 5-Fluorouracil) …
Cytotoxic Activity, Apoptosis Induction and Cell Cycle Arrest in Human Breast Cancer (MCF7) Cells by a Novel Fluorinated Tetrahydro-[1,2,4]Triazolo[3,4-a] …
A series of fluorinated chalcones (3a-f) was synthesized and confirmed by several spectral
tools. The cytotoxic effect of this series was tested against a panel of different cancer cell …
tools. The cytotoxic effect of this series was tested against a panel of different cancer cell …
Novel Bis (2‐cyanoacrylamide) Linked to Sulphamethoxazole: Synthesis, DNA Interaction, Anticancer, ADMET, Molecular Docking, and DFT Studies
In the light of advancement and potential extensive use of medication design and therapy,
new bis (cyanoacrylamides) incorporating sulphamethoxazole derivatives (7 a–7 f) were …
new bis (cyanoacrylamides) incorporating sulphamethoxazole derivatives (7 a–7 f) were …