Valvular heart disease is a major cause of morbidity and mortality worldwide. Surgical valve
repair or replacement has been the standard of care for patients with valvular heart disease …

One of the most remarkable differences between classical engineering materials and living
matter is the ability of the latter to grow and remodel in response to diverse stimuli. The …

Soft biological tissues compromise diverse cell types and extracellular matrix constituents,
each of which can possess individual natural configurations, material properties, and rates …

Thoracic aortic aneurysm (TAA) is a localized dilatation of the aorta that can lead to life-
threatening dissection or rupture. In vivo assessments of TAA progression are largely limited …

Arterial growth and remodeling at the tissue level is driven by mechanobiological processes
at cellular and sub-cellular levels. Although it is widely accepted that cells seek to promote …

Hypertension induces significant aortic remodelling, often adaptive but sometimes not. To
identify immuno-mechanical mechanisms responsible for differential remodelling, we …

Tissue-level biomechanical properties and function derive from underlying cell signaling,
which regulates mass deposition, organization, and removal. Here, we couple two existing …

Cardiac growth and remodeling (G&R) patterns change ventricular size, shape, and function
both globally and locally. Biomechanical, neurohormonal, and genetic stimuli drive these …

We implement full, three-dimensional constrained mixture theory for vascular growth and
remodeling into a finite element fluid–structure interaction (FSI) solver. The resulting “fluid …

Background: Coarctation of the aorta (CoA; constriction of the proximal descending thoracic
aorta) is among the most common congenital cardiovascular defects. Coarctation-induced …