Mechanisms of glutamate release from astrocytes

EB Malarkey, V Parpura - Neurochemistry international, 2008 - Elsevier
Astrocytes can release the excitatory transmitter glutamate which is capable of modulating
activity in nearby neurons. This astrocytic glutamate release can occur through six known …

Gliotransmission and the tripartite synapse

M Santello, C Calì, P Bezzi - Synaptic plasticity: Dynamics, development …, 2012 - Springer
In the last years, the classical view of glial cells (in particular of astrocytes) as a simple
supportive cell for neurons has been replaced by a new vision in which glial cells are active …

Revealing the contribution of astrocytes to glutamatergic neuronal transmission

AO Cuellar-Santoyo, VM Ruiz-Rodríguez… - Frontiers in cellular …, 2023 - frontiersin.org
Research on glutamatergic neurotransmission has focused mainly on the function of
presynaptic and postsynaptic neurons, leaving astrocytes with a secondary role only to …

Thyroid hormone increases astrocytic glutamate uptake and protects astrocytes and neurons against glutamate toxicity

CBN Mendes‐de‐Aguiar, R Alchini… - Journal of …, 2008 - Wiley Online Library
Thyroid hormone (T3) regulates the growth and differentiation of rat cerebellar astrocytes.
Previously, we have demonstrated that these effects are due, at least in part, to the …

Activation of CysLT receptors induces astrocyte proliferation and death after oxygen–glucose deprivation

XJ Huang, WP Zhang, CT Li, WZ Shi, SH Fang, YB Lu… - Glia, 2008 - Wiley Online Library
We recently found that 5‐lipoxygenase (5‐LOX) is activated to produce cysteinyl
leukotrienes (CysLTs), and CysLTs may cause neuronal injury and astrocytosis through …

Thyroid hormone and astroglia: endocrine control of the neural environment

RS Dezonne, FRS Lima, AG Trentin… - Journal of …, 2015 - Wiley Online Library
Thyroid hormones (TH s) play key roles in brain development and function. The lack of TH s
during childhood is associated with the impairment of several neuronal connections …

Inhibition of the mitochondrial glutamate carrier SLC25A22 in astrocytes leads to intracellular glutamate accumulation

E Goubert, Y Mircheva, FM Lasorsa, C Melon… - Frontiers in cellular …, 2017 - frontiersin.org
The solute carrier family 25 (SLC25) drives the import of a large diversity of metabolites into
mitochondria, a key cellular structure involved in many metabolic functions. Mutations of the …

Glutamine synthetase becomes nitrated and its activity is reduced during repetitive seizure activity in the pentylentetrazole model of epilepsy

HJ Bidmon, B Görg, N Palomero‐Gallagher… - …, 2008 - Wiley Online Library
Purpose: The astrocyte‐specific glutamine synthetase (GS) plays a key role in glutamate
recycling and Gamma‐aminobutyric acid (GABA) metabolism. Changes in the expression or …

Dendritic mRNA targeting and translation

S Kindler, HJ Kreienkamp - Synaptic Plasticity: Dynamics, Development …, 2012 - Springer
Selective targeting of specific mRNAs into neuronal dendrites and their locally regulated
translation at particular cell contact sites contribute to input-specific synaptic plasticity. Thus …

Prolonged activation of ERK triggers glutamate‐induced apoptosis of astrocytes: neuroprotective effect of FK506

K Szydlowska, A Gozdz, M Dabrowski… - Journal of …, 2010 - Wiley Online Library
J. Neurochem.(2010) 113, 904–918. Abstract Although, astrocytes are more resistant than
neurons to ischemic injury, astrocyte death has been demonstrated in animal models of …