Melanoma is the most lethal skin cancer that originates from the malignant transformation of
melanocytes. Although melanoma has long been regarded as a cancerous malignancy with …

▪ Abstract Tight control of cell-cell communication is essential for the generation of a
normally patterned embryo. A critical mediator of key cell-cell signaling events during …

The Snail superfamily of zinc-finger transcription factors is involved in processes that imply
pronounced cell movements, both during embryonic development and in the acquisition of …

Wnt signaling controls a variety of developmental and homeostatic events. As a key
component of Wnt signaling, Dishevelled (Dvl/Dsh) protein relays Wnt signals from receptors …

Neural crest cells are multipotential stem cells that contribute extensively to vertebrate
development and give rise to various cell and tissue types. Determination of the fate of …

The Wnt family of secreted signalling molecules are essential in embryo development and
tumour formation. The Frizzled (Fz) family of serpentine receptors function as Wnt …

ABSTRACT β-Catenin is a central component of both the cadherin-catenin cell adhesion
complex and the Wnt signaling pathway. We have investigated the role of β-catenin during …

▪ Abstract The first mouse microphthalmia transcription factor (Mitf) mutation was discovered
over 60 years ago, and since then over 24 spontaneous and induced mutations have been …

Cross-presentation of cell-associated antigens plays an important role in regulating CD8+ T
cell responses to proteins that are not expressed by antigen-presenting cells (APCs) …

Microphthalmia-associated transcription factor (MITF) is an important regulator of
melanogenesis and melanocyte development. Although it has been studied extensively in …