In light of the increasing global burden of new HIV infections, growing financial
requirements, and shifting funding landscape, the global health community must accelerate …

BACKGROUND Reproductive tract infection is an important factor leading to male and
female infertility. Among female infertility factors, microbial and viral infections are the main …

Abstract Background To inform World Health Organization (WHO) global guidelines, we
updated and expanded the evidence base to assess the comparative efficacy, tolerability …

Different mechanisms mediate the toxicity of RNA. Genomic retroviral mRNA hijacks infected
host cell factors to enable virus replication. The viral genomic RNA of the human …

Viral infections are a common cause of morbidity worldwide. The emergence of Coronavirus
Disease 2019 (COVID-19) has led to more attention to viral infections and finding novel …

Introduction: Knowledge of HIV status relies on accurate HIV testing, and is the first step
towards access to HIV treatment and prevention programmes. Globally, HIV-status …

Highlights•During ART, HIV persists latently in several cell types and tissues.•Proliferation of
latently infected cells is likely responsible for residual viremia.•DRMs do not appear during …

Background Children living with human immunodeficiency virus (HIV) infection require
lifelong effective antiretroviral therapy (ART). The goal of ART in HIV-infected persons is …

Background Implementation of ultrasensitive HIV drug resistance tests for routine clinical
use is hampered by uncertainty about the clinical relevance of drug-resistant minority …

Background Paediatric dolutegravir doses approved by stringent regulatory authorities
(SRAs) for children weighing 20 kg to less than 40 kg until recently required 25 mg and 10 …