The global surge of antimicrobial resistance (AMR) is a major concern for public health and
proving to be a key challenge in modern disease treatment, requiring action plans at all …

Introduction Off-label use of medicines is generally discouraged. However, several off-
patent, low-cost cancer medicines remain off-label for indications in which they are …

In Europe, inappropriate reimbursement and funding rules and regulations act as
disincentives to best breast cancer care or, at worst, hinder best care. This problem was the …

Background: Countries are struggling to provide affordable access to medicines while
supporting the market entry of innovative, expensive products. This Perspective aims to …

Background Once a drug gets FDA approved, researchers often attempt to discover new
applications in different indications. The clinical impact of such post-approval activities is …

Purpose Medicines in special situations (MSS) refer to off‐label or to unlicensed drugs
under investigation (compassionate use). Our objectives were to evaluate characteristics …

Major mental disorders, such as schizophrenia, bipolar disorder, and major depressive
disorder, represent the leading cause of disability worldwide. Nevertheless, the current …

Timely and comprehensive updating of treatment guidelines remains a challenge and
necessity in medical oncology. Herein we discuss our assessment of how trial results with …

After marketing authorisation, the development of a medicinal product often continues with
studies investigating new therapeutic indications. Positive results can potentially lead to …

Применение противоопухолевых лекарственных препаратов «вне инструкции» широко
распространено в современной онкологии. Потенциальные преимущества подобных …