Tau is well established as a microtubule-associated protein in neurons. However, under
pathological conditions, aberrant assembly of tau into insoluble aggregates is accompanied …

Abstract Alzheimer's disease (AD), the most common neurodegenerative disorder, is
characterized by memory loss and cognitive dysfunction. The accumulation of misfolded …

Tau protein plays a critical role in the assembly, stabilization, and modulation of
microtubules, which are important for the normal function of neurons and the brain. In …

Abnormalities of the endosomal–lysosomal network (ELN) are a signature feature of
Alzheimer's disease (AD). These include the earliest known cytopathology that is specific to …

Aggregates of the microtubule-associated protein tau are a defining feature of several
neurodegenerative diseases that are collectively known as tauopathies, and constitute one …

Tau is a microtubule-associated protein with versatile functions in the dynamic assembly of
the neuronal cytoskeleton. Four-repeat (4R-) tauopathies are a group of neurodegenerative …

Tau is a protein that is highly enriched in neurons and was originally defined by its ability to
bind and stabilize microtubules. However, it is now becoming evident that the functions of …

Mitochondrial abnormalities have been documented in Alzheimer's disease and related
neurodegenerative disorders, but the causal relationship between mitochondrial changes …

Deposition of tau protein aggregates in the brain of affected individuals is a defining feature
of “tauopathies,” including Alzheimer's disease. Studies of human brain tissue and various …

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a pivotal transcription factor in the defence
against oxidative stress. Here we provide evidence that activation of the Nrf2 pathway …