Cancer stem cell–immune cell crosstalk in tumour progression
Cellular heterogeneity and an immunosuppressive tumour microenvironment are
independent yet synergistic drivers of tumour progression and underlie therapeutic …
independent yet synergistic drivers of tumour progression and underlie therapeutic …
[HTML][HTML] Defining trained immunity and its role in health and disease
Immune memory is a defining feature of the acquired immune system, but activation of the
innate immune system can also result in enhanced responsiveness to subsequent triggers …
innate immune system can also result in enhanced responsiveness to subsequent triggers …
Interleukin-17 governs hypoxic adaptation of injured epithelium
Mammalian cells autonomously activate hypoxia-inducible transcription factors (HIFs) to
ensure survival in low-oxygen environments. We report here that injury-induced hypoxia is …
ensure survival in low-oxygen environments. We report here that injury-induced hypoxia is …
Biomimetic glycopeptide hydrogel coated PCL/nHA scaffold for enhanced cranial bone regeneration via macrophage M2 polarization-induced osteo …
The reconstruction of large cranial bone defects by bioactive materials without exogenous
cells or growth factors remains a substantial clinical challenge. Here, synthetic fibrous …
cells or growth factors remains a substantial clinical challenge. Here, synthetic fibrous …
Trained immunity: adaptation within innate immune mechanisms
J Domínguez-Andrés, JC Dos Santos… - Physiological …, 2023 - journals.physiology.org
The mechanisms underlying innate immune memory have been extensively explored in the
last decades but are in fact largely unknown. Although the specificity of adaptive immune …
last decades but are in fact largely unknown. Although the specificity of adaptive immune …
[HTML][HTML] Advancing application of mesenchymal stem cell-based bone tissue regeneration
F Shang, Y Yu, S Liu, L Ming, Y Zhang, Z Zhou, J Zhao… - Bioactive materials, 2021 - Elsevier
Reconstruction of bone defects, especially the critical-sized defects, with mechanical
integrity to the skeleton is important for a patient's rehabilitation, however, it still remains …
integrity to the skeleton is important for a patient's rehabilitation, however, it still remains …
[HTML][HTML] Establishment, maintenance, and recall of inflammatory memory
Known for nearly a century but through mechanisms that remain elusive, cells retain a
memory of inflammation that equips them to react quickly and broadly to diverse secondary …
memory of inflammation that equips them to react quickly and broadly to diverse secondary …
T cell stemness and dysfunction in tumors are triggered by a common mechanism
INTRODUCTION Cancers persist and progress despite the presence of tumor-infiltrating
lymphocytes (TILs). A paradox of tumor immunology is that tumor antigen–specific TILs are …
lymphocytes (TILs). A paradox of tumor immunology is that tumor antigen–specific TILs are …
[HTML][HTML] Tissue stem cells: architects of their niches
E Fuchs, HM Blau - Cell stem cell, 2020 - cell.com
Stem cells (SCs) maintain tissue homeostasis and repair wounds. Despite marked variation
in tissue architecture and regenerative demands, SCs often follow similar paradigms in …
in tissue architecture and regenerative demands, SCs often follow similar paradigms in …
[HTML][HTML] Genetically engineered myeloid cells rebalance the core immune suppression program in metastasis
S Kaczanowska, DW Beury, V Gopalan, AK Tycko… - Cell, 2021 - cell.com
Metastasis is the leading cause of cancer-related deaths, and greater knowledge of the
metastatic microenvironment is necessary to effectively target this process …
metastatic microenvironment is necessary to effectively target this process …