Antiretroviral therapy can effectively block HIV-1 replication and prevent or reverse
immunodeficiency in HIV-1-infected individuals. However, viral replication resumes within …

A multitude of new agents for the treatment of hematologic malignancies has been
introduced over the past decade. Hematologists, infectious disease specialists, stem cell …

Fibrosis usually results from dysregulated wound repair and is characterized by excessive
scar tissue. It is a complex process with unclear mechanisms. Accumulating evidence …

Current antiretroviral therapy does not eliminate the integrated and transcriptionally silent
HIV-1 provirus in latently infected cells. Recently, a “shock and kill” strategy has been …

Dendritic cells (DCs) play important roles in orchestrating host immunity against invading
pathogens, representing one of the first responders to infection by mucosal invaders. From …

Thirty-five years after the identification of HIV-1 as the causative agent of AIDS, we are still in
search of vaccines and treatments to eradicate this devastating infectious disease. Progress …

Human immunodeficiency virus (HIV) infection induces immunological dysfunction, which
limits the elimination of HIV-infected cells during treated infection. Identifying and targeting …

The introduction of antiretroviral therapy (ART) 20 years ago has dramatically reduced
morbidity and mortality associated with HIV-1. Initially there was hope that ART would be …

More effective latency-reversing interventions and additional strategies to eliminate virus-
expressing cells are needed. Key challenges include testing combinations of LRAs and/or …

Residual inflammation and viral reservoirs: alliance against... : Current Opinion in HIV and
AIDS Residual inflammation and viral reservoirs: alliance against an HIV cure : Current …