[HTML][HTML] The relevance of oxidative stress in the pathogenesis and therapy of retinal dystrophies

E B. Domènech, G Marfany - Antioxidants, 2020 - mdpi.com
Retinal cell survival requires an equilibrium between oxygen, reactive oxygen species, and
antioxidant molecules that counteract oxidative stress damage. Oxidative stress alters cell …

[HTML][HTML] Reactive oxygen species-mediated damage of retinal neurons: Drug development targets for therapies of chronic neurodegeneration of the retina

LJ Rohowetz, JG Kraus, P Koulen - International Journal of Molecular …, 2018 - mdpi.com
The significance of oxidative stress in the development of chronic neurodegenerative
diseases of the retina has become increasingly apparent in recent years. Reactive oxygen …

[HTML][HTML] Regulation of adhesion dynamics by calpain-mediated proteolysis of focal adhesion kinase (FAK)

KT Chan, DA Bennin, A Huttenlocher - Journal of Biological Chemistry, 2010 - ASBMB
The coordinated and dynamic regulation of adhesions is required for cell migration. We
demonstrated previously that limited proteolysis of talin1 by the calcium-dependent protease …

[HTML][HTML] Two combined photosensitizers: a goal for more effective photodynamic therapy of cancer

P Acedo, JC Stockert, M Cañete, A Villanueva - Cell death & disease, 2014 - nature.com
Photodynamic therapy (PDT) is a clinically approved therapeutic modality for the treatment
of diseases characterized by uncontrolled cell proliferation, mainly cancer. It involves the …

Zn-doped MnO2 nanocoating with enhanced catalase-mimetic activity and cytocompatibility protects pre-osteoblasts against H2O2-induced oxidative stress

S Liu, K Li, T Hu, D Shao, S Huang, Y Xie… - Colloids and Surfaces B …, 2021 - Elsevier
Therapeutic application in prevention and treatment of bone diseases, particularly
osteoporosis, has recently started to emerge for manganese dioxide (MnO 2) nanoparticles …

miR-193b–Regulated Signaling Networks Serve as Tumor Suppressors in Liposarcoma and Promote Adipogenesis in Adipose-Derived Stem Cells

YZ Mazzu, Y Hu, RK Soni, KM Mojica, LX Qin, P Agius… - Cancer research, 2017 - AACR
Well-differentiated and dedifferentiated liposarcomas (WDLS/DDLS) account for
approximately 13% of all soft tissue sarcoma in adults and cause substantial morbidity or …

The role of focal adhesion kinase in the regulation of cellular mechanical properties

CT Mierke - Physical biology, 2013 - iopscience.iop.org
The regulation of mechanical properties is necessary for cell invasion into connective tissue
or intra-and extravasation through the endothelium of blood or lymph vessels. Cell invasion …

Autism spectrum disorders may be due to cerebral toxoplasmosis associated with chronic neuroinflammation causing persistent hypercytokinemia that resulted in an …

J Prandota - Research in Autism Spectrum Disorders, 2010 - Elsevier
Worldwide, approximately 2 billion people are chronically infected with Toxoplasma gondii
with largely yet unknown consequences. Patients with autism spectrum disorders (ASD) …

[HTML][HTML] MCL1 Inhibition Overcomes the Aggressiveness Features of Triple-Negative Breast Cancer MDA-MB-231 Cells

G Pratelli, D Carlisi, D Di Liberto, A Notaro… - International Journal of …, 2023 - mdpi.com
Triple-Negative Breast Cancer (TNBC) is a particularly aggressive subtype among breast
cancers (BCs), characterized by anoikis resistance, high invasiveness, and metastatic …

[HTML][HTML] Radiation sensitization of tumor cells induced by shear stress: The roles of integrins and FAK

CW Luo, CC Wu, HJ Ch'ang - … et Biophysica Acta (BBA)-Molecular Cell …, 2014 - Elsevier
Recent studies revealed that the interstitial fluid flow in and around tumor tissue not only
played an important role in delivering anticancer agents, but also affected the …