The tumor microenvironment favors the growth and expansion of cancer cells. Many cell
types are involved in the tumor microenvironment such as inflammatory cells, fibroblasts …

Gastric cancer is a major source of global cancer mortality with limited treatment options and
poor patient survival. As our molecular understanding of gastric cancer improves, we are …

Parietal cells are responsible for gastric acid secretion, which aids in the digestion of food,
absorption of minerals, and control of harmful bacteria. However, a fine balance of activators …

The past decade has witnessed groundbreaking advances in the field of microbiome
research. An area where immense implications of the microbiome have been demonstrated …

The nervous system plays an important role in the regulation of epithelial homeostasis and
has also been postulated to play a role in tumorigenesis. We provide evidence that proper …

The stomach is traditionally regarded as a hollow muscular sac that initiates the second
phase of digestion. Yet this simple view ignores the fact that it is the most sophisticated …

Gastric cancer represents one of the leading causes of cancer deaths worldwide.
Helicobacter pylori (H. pylori) infection is the strongest risk factor associated with gastric …

Helicobacter pylori is the first formally recognized bacterial carcinogen and is one of the
most successful human pathogens, as over half of the world's population is colonized with …

The mucosa of the body of the stomach (ie, the gastric corpus) uses 2 overlapping, depth-
dependent mechanisms to respond to injury. Superficial injury heals via surface cells with …

Cancer stem cells (CSCs) have been defined as a unique subpopulation in tumors that
possess the ability to initiate tumor growth and sustain tumor self-renewal. Although the …