Receptor for advanced glycation end products (RAGE) and mechanisms and therapeutic opportunities in diabetes and cardiovascular disease: insights from human …

L Egaña-Gorroño, R López-Díez, G Yepuri… - Frontiers in …, 2020 - frontiersin.org
Obesity and diabetes are leading causes of cardiovascular morbidity and mortality. Although
extensive strides have been made in the treatments for non-diabetic atherosclerosis and its …

[HTML][HTML] The use of the soluble receptor for advanced glycation-end products (sRAGE) as a potential biomarker of disease risk and adverse outcomes

JD Erusalimsky - Redox Biology, 2021 - Elsevier
The soluble receptor for advanced glycation end-products (sRAGE) has been classically
considered a sink for pro-inflammatory RAGE ligands and as such has been associated with …

Therapy-induced evolution of human lung cancer revealed by single-cell RNA sequencing

A Maynard, CE McCoach, JK Rotow, L Harris, F Haderk… - Cell, 2020 - cell.com
Lung cancer, the leading cause of cancer mortality, exhibits heterogeneity that enables
adaptability, limits therapeutic success, and remains incompletely understood. Single-cell …

Mechanistic insights into the alterations and regulation of the AKT signaling pathway in diabetic retinopathy

J Li, K Chen, X Li, X Zhang, L Zhang, Q Yang… - Cell Death …, 2023 - nature.com
In the early stages of diabetic retinopathy (DR), diabetes-related hyperglycemia directly
inhibits the AKT signaling pathway by increasing oxidative stress or inhibiting growth factor …

The role of berberine in Covid-19: potential adjunct therapy

AO Babalghith, HM Al-Kuraishy, AI Al-Gareeb… - …, 2022 - Springer
Abstract Coronavirus disease 2019 (Covid-19) is a global diastrophic disease caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Covid-19 leads to …

The AGE-RAGE axis and RAGE genetics in chronic obstructive pulmonary disease

A Sharma, S Kaur, M Sarkar, BC Sarin… - Clinical Reviews in …, 2021 - Springer
Chronic obstructive pulmonary disease (COPD) is a heterogeneous group of lung diseases
limiting the airflow due to narrowing of airways, chronic bronchitis and emphysema that …

The AGE-RAGE Axis and the Pathophysiology of Multimorbidity in COPD

NL Reynaert, LEGW Vanfleteren… - Journal of Clinical …, 2023 - mdpi.com
Chronic obstructive pulmonary disease (COPD) is a disease of the airways and lungs due to
an enhanced inflammatory response, commonly caused by cigarette smoking. Patients with …

Testosterone in COVID-19: an adversary bane or comrade boon

HM Al-Kuraishy, AI Al-Gareeb, H Faidah… - Frontiers in cellular …, 2021 - frontiersin.org
COVID-19 is a pandemic disease caused by severe acute respiratory coronavirus 2 (SARS-
CoV-2), which leads to pulmonary manifestations like acute lung injury (ALI) and acute …

Role of RAGE in the Pathogenesis of Neurological Disorders

J Juranek, K Mukherjee, B Kordas, M Załęcki… - Neuroscience …, 2022 - Springer
This review reflects upon our own as well as other investigators' studies on the role of
receptor for advanced glycation end-products (RAGE), bringing up the latest information on …

Hyperactivated RAGE in comorbidities as a risk factor for severe COVID-19—The role of RAGE-Ras crosstalk

S Chiappalupi, L Salvadori, R Donato, F Riuzzi, G Sorci - Biomolecules, 2021 - mdpi.com
The receptor for advanced glycation-end products (RAGE) is a multiligand receptor with a
role in inflammatory and pulmonary pathologies. Hyperactivation of RAGE by its ligands has …