The neurobiology of fear generalization
The generalization of fear memories is an adaptive neurobiological process that promotes
survival in complex and dynamic environments. When confronted with a potential threat, an …
survival in complex and dynamic environments. When confronted with a potential threat, an …
Laboratory models of post-traumatic stress disorder: The elusive bridge to translation
Post-traumatic stress disorder (PTSD) is a debilitating mental illness composed of a
heterogeneous collection of symptom clusters. The unique nature of PTSD as arising from a …
heterogeneous collection of symptom clusters. The unique nature of PTSD as arising from a …
Dendritic spine plasticity: function and mechanisms
K Runge, C Cardoso, A De Chevigny - Frontiers in synaptic …, 2020 - frontiersin.org
Dendritic spines are small protrusions studding neuronal dendrites, first described in 1888
by Ramón y Cajal using his famous Golgi stainings. Around 50 years later the advance of …
by Ramón y Cajal using his famous Golgi stainings. Around 50 years later the advance of …
[HTML][HTML] Microglia mediate postoperative hippocampal inflammation and cognitive decline in mice
X Feng, M Valdearcos, Y Uchida, D Lutrin, M Maze… - JCI insight, 2017 - ncbi.nlm.nih.gov
Surgery can induce cognitive decline, a risk that increases with advancing age. In rodents,
postoperative cognitive decline (POCD) is associated with the inflammatory activation of …
postoperative cognitive decline (POCD) is associated with the inflammatory activation of …
Systems consolidation induces multiple memory engrams for a flexible recall strategy in observational fear memory in male mice
Observers learn to fear the context in which they witnessed a demonstrator's aversive
experience, called observational contextual fear conditioning (CFC). The neural …
experience, called observational contextual fear conditioning (CFC). The neural …
Dentate granule cell recruitment of feedforward inhibition governs engram maintenance and remote memory generalization
Memories become less precise and generalized over time as memory traces reorganize in
hippocampal–cortical networks. Increased time-dependent loss of memory precision is …
hippocampal–cortical networks. Increased time-dependent loss of memory precision is …
Microglial cell hyper-ramification and neuronal dendritic spine loss in the hippocampus and medial prefrontal cortex in a mouse model of PTSD
Few animal models exist that successfully reproduce several core associative and non-
associative behaviours relevant to post-traumatic stress disorder (PTSD), such as long …
associative behaviours relevant to post-traumatic stress disorder (PTSD), such as long …
Designing animal-friendly behavioral tests for neuroscience research: the importance of an ethological approach
Behavioral tests have three key elements:(1) a motivating factor (what motivates the animal
in the test);(2) an observable behavior (which behaviors we may expect the animal exhibits …
in the test);(2) an observable behavior (which behaviors we may expect the animal exhibits …
Effects of motivational climate on fear of failure and anxiety in teen handball players
M Gómez-López, C Chicau Borrego… - International journal of …, 2020 - mdpi.com
The aim of this study was to examine the effects of the motivational climate created by the
coach and perceived by a group of young, high-performance handball players on their fear …
coach and perceived by a group of young, high-performance handball players on their fear …
Know thy SEFL: Fear sensitization and its relevance to stressor-related disorders
Extreme stress can cause long-lasting changes in affective behavior manifesting in
conditions such as post-traumatic stress disorder (PTSD). Understanding the biological …
conditions such as post-traumatic stress disorder (PTSD). Understanding the biological …