Metagenomics for neurological infections—expanding our imagination
PS Ramachandran, MR Wilson - Nature Reviews Neurology, 2020 - nature.com
Over the past two decades, the diagnosis rate for patients with encephalitis has remained
poor despite advances in pathogen-specific testing such as PCR and antigen assays …
poor despite advances in pathogen-specific testing such as PCR and antigen assays …
Neuropathology of new-onset refractory status epilepticus (NORSE)
Abstract New-Onset Refractory Status Epilepticus (NORSE), including its subtype with a
preceding febrile illness known as FIRES (Febrile Infection-Related Epilepsy Syndrome), is …
preceding febrile illness known as FIRES (Febrile Infection-Related Epilepsy Syndrome), is …
Discovering disease-causing pathogens in resource-scarce Southeast Asia using a global metagenomic pathogen monitoring system
Understanding the regional pathogen landscape and surveillance of emerging pathogens is
key to mitigating epidemics. Challenges lie in resource-scarce settings, where outbreaks are …
key to mitigating epidemics. Challenges lie in resource-scarce settings, where outbreaks are …
First case of lethal encephalitis in Western Europe due to European bat lyssavirus type 1
B Regnault, B Evrard, I Plu, L Dacheux… - Clinical Infectious …, 2022 - academic.oup.com
Background Inaccurate diagnosis of encephalitis is a major issue as immunosuppressive
treatments can be deleterious in case of viral infection. The European bat lyssavirus type 1 …
treatments can be deleterious in case of viral infection. The European bat lyssavirus type 1 …
A broad wastewater screening and clinical data surveillance for virus-related diseases in the metropolitan Detroit area in Michigan
Background Periodic bioinformatics-based screening of wastewater for assessing the
diversity of potential human viral pathogens circulating in a given community may help to …
diversity of potential human viral pathogens circulating in a given community may help to …
The orthobunyavirus germiston enters host cells from late endosomes
S Windhaber, Q Xin, ZM Uckeley, J Koch, M Obr… - Journal of …, 2022 - Am Soc Microbiol
With more than 80 members worldwide, the Orthobunyavirus genus in the Peribunyaviridae
family is a large genus of enveloped RNA viruses, many of which are emerging pathogens …
family is a large genus of enveloped RNA viruses, many of which are emerging pathogens …
The native orthobunyavirus ribonucleoprotein possesses a helical architecture
The Bunyavirales order is the largest group of negative-sense RNA viruses, containing
many lethal human pathogens for which approved anti-infective measures are not available …
many lethal human pathogens for which approved anti-infective measures are not available …
Chronic aichi virus infection as a cause of long-lasting multiorgan involvement in patients with primary immune deficiencies
J Fourgeaud, MM Lecuit, P Pérot… - Clinical Infectious …, 2023 - academic.oup.com
Background Metagenomic next-generation sequencing (mNGS) was used to assess
patients with primary or secondary immune deficiencies (PIDs and SIDs) who presented with …
patients with primary or secondary immune deficiencies (PIDs and SIDs) who presented with …
Structure, function, and evolution of the Orthobunyavirus membrane fusion glycoprotein
J Hellert, A Aebischer, A Haouz, P Guardado-Calvo… - Cell Reports, 2023 - cell.com
La Crosse virus, responsible for pediatric encephalitis in the United States, and
Schmallenberg virus, a highly teratogenic veterinary virus in Europe, belong to the large …
Schmallenberg virus, a highly teratogenic veterinary virus in Europe, belong to the large …
Performance of clinical metagenomics in France: a prospective observational study
J Fourgeaud, B Regnault, V Ok, N Da Rocha… - The Lancet …, 2024 - thelancet.com
Background Metagenomic next-generation sequencing (mNGS) allows untargeted
identification of a broad range of pathogens, including rare or novel microorganisms …
identification of a broad range of pathogens, including rare or novel microorganisms …