The complexity and delicacy of human brain make it challenging to recapitulate its
development, function and disorders. Brain organoids derived from human pluripotent stem …

Ubiquitous expression of GABA type A receptors (GABAAR) in the central nervous system
establishes their central role in coordinating most aspects of neural function and …

Background The purpose of this study was to conduct a 20-week controlled trial of lovastatin
(10 to 40 mg/day) in youth with fragile X syndrome (FXS) ages 10 to 17 years, combined with …

Fragile X mental retardation protein (FMRP) is absent or highly reduced in Fragile X
Syndrome, a genetic disorder causing cognitive impairment and autistic behaviors. Previous …

Optogenetics—the use of light and genetics to manipulate and monitor the activities of
defined cell populations—has already had a transformative impact on basic neuroscience …

Introduction: Rett syndrome (RTT) is an X-linked neurodevelopmental disorder that primarily
affects females, typically resulting in a period of developmental regression in early childhood …

Autism spectrum disorder (ASD) affects approximately 1% of the human population and has
a strong genetic component. Hence, the recent discovery of major “ASD genes” has …

The protein complex formed by the Ca2+ sensor neuronal calcium sensor 1 (NCS-1) and the
guanine exchange factor protein Ric8a coregulates synapse number and probability of …

Rett syndrome (RTT) is a neurodevelopmental disorder that primarily affects females.
Recent work indicates the potential for disease modifying therapies. However, there remains …

Fragile X syndrome (FXS), the leading cause of inherited forms of mental retardation and
autism, is caused by the transcriptional silencing of fmr1 encoding the fragile X mental …