Despite the advent of sophisticated and efficient new biologics to treat inflammation in
asthma, the disease persists. Even following treatment, many patients still experience the …

Mucus is a complex biological material that lubricates and protects the human lungs,
gastrointestinal (GI) tract, vagina, eyes, and other moist mucosal surfaces. Mucus serves as …

Primary ciliary dyskinesia (PCD) is a rare genetic ciliopathy in which mucociliary clearance
is disturbed by the abnormal motion of cilia or there is a severe reduction in the generation …

This comprehensive State of the Art review summarizes the current published knowledge
base regarding the pathophysiology and microbiology of pulmonary disease in cystic …

Background Inhaled hypertonic saline acutely increases mucociliary clearance and, in short-
term trials, improves lung function in people with cystic fibrosis. We tested the safety and …

Abbreviations: ADA Americans with Disabilities Act; BMD bone mineral density; BMI body
mass index; CBAVD congenital bilateral absence of the vas deferens; CF cystic fibrosis; CFF …

Background Dornase alfa is currently used as a mucolytic to treat pulmonary disease (the
major cause of morbidity and mortality) in cystic fibrosis. It reduces mucus viscosity in the …

Biofilms of various Pseudomonas aeruginosa strains were grown in glass flow cells under
laminar and turbulent flows. By relating the physical deformation of biofilms to variations in …

The survival of patients with cystic fibrosis (CF) continues to improve. The discovery and
cloning of the CFTR gene more than 21 years ago led to the identification of the structure …

Background Hypertonic saline enhances mucociliary clearance and may lessen the
destructive inflammatory process in the airways. This is an update of a previously published …