Magnetization transfer contrast and chemical exchange saturation transfer MRI. Features and analysis of the field-dependent saturation spectrum

PCM Van Zijl, WW Lam, J Xu, L Knutsson, GJ Stanisz - Neuroimage, 2018 - Elsevier
Abstract Magnetization Transfer Contrast (MTC) and Chemical Exchange Saturation
Transfer (CEST) experiments measure the transfer of magnetization from molecular protons …

Genetic variations influence brain changes in patients with attention-deficit hyperactivity disorder

SK Yadav, AA Bhat, S Hashem, S Nisar… - Translational …, 2021 - nature.com
Attention-deficit hyperactivity disorder (ADHD) is a neurological and neurodevelopmental
childhood-onset disorder characterized by a persistent pattern of inattentiveness …

Friend or foe? Defining the role of glutamate in aging and Alzheimer's disease

MKF Cox, ER Hascup, A Bartke, KN Hascup - Frontiers in Aging, 2022 - frontiersin.org
Aging is a naturally occurring decline of physiological processes and biological pathways
that affects both the structural and functional integrity of the body and brain. These …

Imaging synaptic density: the next holy grail of neuroscience?

ME Serrano, E Kim, MM Petrinovic… - Frontiers in …, 2022 - frontiersin.org
The brain is the central and most complex organ in the nervous system, comprising billions
of neurons that constantly communicate through trillions of connections called synapses …

Glutamate imaging (GluCEST) lateralizes epileptic foci in nonlesional temporal lobe epilepsy

KA Davis, RPR Nanga, S Das, SH Chen… - Science translational …, 2015 - science.org
When neuroimaging reveals a brain lesion, drug-resistant epilepsy patients show better
outcomes after resective surgery than do the one-third of drug-resistant epilepsy patients …

In vivo Imaging of Glial Activation in Alzheimer's Disease

P Edison, CK Donat, M Sastre - Frontiers in neurology, 2018 - frontiersin.org
Alzheimer's disease (AD) is characterized by memory loss and decline of cognitive function,
associated with progressive neurodegeneration. While neuropathological processes like …

Glutamate imaging (GluCEST) reveals lower brain GluCEST contrast in patients on the psychosis spectrum

DR Roalf, RPR Nanga, PE Rupert, H Hariharan… - Molecular …, 2017 - nature.com
Psychosis commonly develops in adolescence or early adulthood. Youths at clinical high
risk (CHR) for psychosis exhibit similar, subtle symptoms to those with schizophrenia (SZ) …

Astrocytes in mouse models of tauopathies acquire early deficits and lose neurosupportive functions

M Sidoryk-Wegrzynowicz, YN Gerber, M Ries… - Acta neuropathologica …, 2017 - Springer
Microtubule-associated protein tau aggregates constitute the characteristic
neuropathological features of several neurodegenerative diseases grouped under the name …

Long-term treadmill exercise attenuates tau pathology in P301S tau transgenic mice

O Ohia-Nwoko, S Montazari, YS Lau… - Molecular …, 2014 - Springer
Background Recent epidemiological evidence suggests that modifying lifestyle by
increasing physical activity could be a non-pharmacological approach to improving …

Glutamate‐weighted CEST (gluCEST) imaging for mapping neurometabolism: An update on the state of the art and emerging findings from in vivo applications

ATJ Cember, RPR Nanga, R Reddy - NMR in Biomedicine, 2023 - Wiley Online Library
Glutamate is the primary excitatory neurotransmitter in the mammalian central nervous
system. As such, its proper regulation is essential to the healthy function of the human brain …