The physics of heart rhythm disorders

WJ Rappel - Physics reports, 2022 - Elsevier
The global burden caused by cardiovascular disease is substantial, with heart disease
representing the most common cause of death around the world. There remains a need to …

The management of ventricular dysrhythmia in aconite poisoning

JM Coulson, TM Caparrotta, JP Thompson - Clinical Toxicology, 2017 - Taylor & Francis
Introduction: Aconite poisoning is relatively rare but is frequently complicated by ventricular
dysrhythmias, which may be fatal. Molecular basis of aconite alkaloid ventricular …

Light-induced termination of spiral wave arrhythmias by optogenetic engineering of atrial cardiomyocytes

BO Bingen, MC Engels, MJ Schalij… - Cardiovascular …, 2014 - academic.oup.com
Aims Atrial fibrillation (AF) is the most common cardiac arrhythmia and often involves
reentrant electrical activation (eg spiral waves). Drug therapy for AF can have serious side …

Imaging the dynamics of individual electropores

JT Sengel, MI Wallace - Proceedings of the National …, 2016 - National Acad Sciences
Electroporation is a widely used technique to permeabilize cell membranes. Despite its
prevalence, our understanding of the mechanism of voltage-mediated pore formation is …

Drift and termination of spiral waves in optogenetically modified cardiac tissue at sub-threshold illumination

S Hussaini, V Venkatesan, V Biasci… - Elife, 2021 - elifesciences.org
The development of new approaches to control cardiac arrhythmias requires a deep
understanding of spiral wave dynamics. Optogenetics offers new possibilities for this …

Nondestructive Electrical Activation Enables Multiple Life Cycles for Degraded Batteries

Y Jiao, F Li, W Mao, H Chen, W Li, E He… - Advanced Functional …, 2024 - Wiley Online Library
Appropriate treatment of mass‐produced degraded batteries is desired to alleviate resource
waste and environmental pollution caused by direct disposal. However, current …

[PDF][PDF] Electroporation-induced changes in normal immature rat myoblasts (H9C2)

I Kaminska, M Kotulska, A Stecka, J Saczko… - Gen Physiol …, 2012 - academia.edu
Application of a high electric field causes an electric shock to the heart. This is utilized in defibrillationtoreestablishnormalcontraction…
arrest. If shock-induced transmembrane potentials are large enough, they can cause tissue …

Terminating spiral waves with a single designed stimulus: Teleportation as the mechanism for defibrillation

N DeTal, A Kaboudian… - Proceedings of the …, 2022 - National Acad Sciences
We identify and demonstrate a universal mechanism for terminating spiral waves in
excitable media using an established topological framework. This mechanism dictates …

Optogenetic termination of cardiac arrhythmia: mechanistic enlightenment and therapeutic application?

P Sasse, M Funken, T Beiert, T Bruegmann - Frontiers in physiology, 2019 - frontiersin.org
Optogenetic methods enable selective de-and hyperpolarization of cardiomyocytes
expressing light-sensitive proteins within the myocardium. By using light, this technology …

Excitation and injury of adult ventricular cardiomyocytes by nano-to millisecond electric shocks

I Semenov, S Grigoryev, JU Neuber, CW Zemlin… - Scientific reports, 2018 - nature.com
Intense electric shocks of nanosecond (ns) duration can become a new modality for more
efficient but safer defibrillation. We extended strength-duration curves for excitation of …