[HTML][HTML] Extracellular vesicle-loaded hydrogels for tissue repair and regeneration

Y Ju, Y Hu, P Yang, X Xie, B Fang - Materials Today Bio, 2023 - Elsevier
Extracellular vesicles (EVs) are a collective term for nanoscale or microscale vesicles
secreted by cells that play important biological roles. Mesenchymal stem cells are a class of …

Applications and advancements of nanoparticle-based drug delivery in alleviating lung cancer and chronic obstructive pulmonary disease

G De Rubis, KR Paudel, L Corrie, S Mehndiratta… - Naunyn-Schmiedeberg's …, 2024 - Springer
Lung cancer (LC) and chronic obstructive pulmonary disease (COPD) are among the
leading causes of mortality worldwide. Cigarette smoking is among the main aetiologic …

Accurate and Convenient Lung Cancer Diagnosis through Detection of Extracellular Vesicle Membrane Proteins via Förster Resonance Energy Transfer

S Xiao, Y Yao, S Liao, B Xu, X Li, Y Zhang, L Zhang… - Nano …, 2023 - ACS Publications
Tumor-derived extracellular vesicles (EVs) are promising to monitor early stage cancer.
Unfortunately, isolating and analyzing EVs from a patient's liquid biopsy are challenging. For …

Delivery systems of therapeutic nucleic acids for the treatment of acute lung injury/acute respiratory distress syndrome

C Zhuang, M Kang, M Lee - Journal of Controlled Release, 2023 - Elsevier
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a devastating
inflammatory lung disease with a high mortality rate. ALI/ARDS is induced by various …

Nebulized milk exosomes loaded with siTGF-β1 ameliorate pulmonary fibrosis by inhibiting EMT pathway and enhancing collagen permeability

C Qiu, Z Zhao, C Xu, R Yuan, Y Ha, Q Tu… - Journal of …, 2024 - Springer
Pulmonary Fibrosis (PF) is a fatal disease in the interstitial lung associated with high
mortality, morbidity, and poor prognosis. Transforming growth factor-β1 (TGF-β1) is a …

[HTML][HTML] Nebulised delivery of RNA formulations to the lungs: From aerosol to cytosol

MT Neary, LM Mulder, PS Kowalski… - Journal of Controlled …, 2024 - Elsevier
In the past decade RNA-based therapies such as small interfering RNA (siRNA) and
messenger RNA (mRNA) have emerged as new and ground-breaking therapeutic agents for …

Recent advances in extracellular vesicles for therapeutic cargo delivery

HI Kim, J Park, Y Zhu, X Wang, Y Han… - Experimental & Molecular …, 2024 - nature.com
Exosomes, which are nanosized vesicles secreted by cells, are attracting increasing interest
in the field of biomedical research due to their unique properties, including biocompatibility …

Unraveling the Multifaceted Roles of Extracellular Vesicles: Insights into Biology, Pharmacology, and Pharmaceutical Applications for Drug Delivery

A Al-Jipouri, À Eritja, M Bozic - International Journal of Molecular …, 2023 - mdpi.com
Extracellular vesicles (EVs) are nanoparticles released from various cell types that have
emerged as powerful new therapeutic option for a variety of diseases. EVs are involved in …

Extracellular vesicle-encapsulated CC16 as novel nanotherapeutics for treatment of acute lung injury

Y Han, Y Zhu, S Almuntashiri, X Wang, PR Somanath… - Molecular Therapy, 2023 - cell.com
Acute lung injury (ALI) is still associated with high mortality. Growing evidence suggests that
Club Cell Protein 16 (CC16) plays a protective role against ALI. However, the doses of …

[HTML][HTML] Schwann cell–derived extracellular vesicles as a potential therapy for retinal ganglion cell degeneration

S Zhu, L Chen, M Wang, J Zhang, G Chen… - Journal of Controlled …, 2023 - Elsevier
Optic neuropathy is the leading cause of irreversible blindness and is characterized by
progressive degeneration of retinal ganglion cells (RGCs). Several studies have …