Genetic and epigenetic modifications in DNA contribute to altered gene expression in aging
and cancer. In human cancers, epigenetic changes such as DNA methylation, histone …

DNA methylation is frequently described as a'silencing'epigenetic mark, and indeed this
function of 5-methylcytosine was originally proposed in the 1970s. Now, thanks to improved …

Retinoblastoma (RB) is a cancer that forms in the developing retina of babies and toddlers.
The goal of therapy is to cure the tumor, save the eye and maximize vision. However, it is …

Chemical carcinogenesis follows a multistep process involving both mutation and increased
cell proliferation. Oxidative stress can occur through overproduction of reactive oxygen and …

The earlier cancer can be detected, the better the chance of a cure. Currently, many cancers
are diagnosed only after they have metastasized throughout the body. Effective, accurate …

DNA methylation is an important regulator of gene transcription, and its role in
carcinogenesis has been a topic of considerable interest in the last few years. Alterations in …

We have come a long way since the first reports of the existence of aberrant DNA
methylation in human cancer. Hypermethylation of CpG islands located in the promoter …

Every year more than 13 million deaths worldwide are due to environmental pollutants, and
approximately 24% of diseases are caused by environmental exposures that might be …

DNA methylation, ie, addition of methyl group to 5′-carbon of cytosine residues in CpG
dinucleotides, is an important epigenetic modification regulating gene expression, and thus …

CpG islands frequently contain gene promoters or exons 1 and are usually unmethylated in
normal cells 1, 2, 3. Methylation of CpG islands is associated with delayed replication …