An association between arteriosclerosis and homocysteine (Hcy) was first demonstrated in
1969. Hcy is a sulfur containing amino acid derived from the essential amino acid …

As the population ages due to demographic trends and gains in life expectancy, the
incidence and prevalence of dementia increases, and the need to understand the etiology …

Vascular insults can initiate a cascade of molecular events leading to neurodegeneration,
cognitive impairment, and dementia. Here, we review the cellular and molecular …

Moderately elevated plasma total homocysteine (tHcy) is a strong modifiable risk factor for
vascular dementia and Alzheimer's disease. Prospectively, elevated tHcy is associated with …

Hyperhomocysteinemia/Homocysteinuria is characterized by an increased level of toxic
homocysteine in the plasma. The plasma concentration of homocysteine is 5–15 μmol/L in …

There are many reasons for reviewing the neurology of vitamin-B12 and folic-acid
deficiencies together, including the intimate relation between the metabolism of the two …

Several commonly prescribed antiepileptic drugs (AEDs)—including phenobarbital,
phenytoin, and carbamazepine—stimulate the synthesis of a broad range of …

The hippocampus is particularly vulnerable to the neurotoxic effects of obesity, diabetes
mellitus, hypertension, hypoxic brain injury, obstructive sleep apnoea, bipolar disorder …

Previous studies suggest a link between chronic kidney disease (CKD) and cognitive
impairment. Whether the longitudinal course of cognitive impairment differs among people …

Background A high circulating concentration of the amino acid homocysteine is an
independent risk factor for stroke. Alzheimer's disease (AD) commonly co-occurs with stroke …