[HTML][HTML] Review of toluene action: clinical evidence, animal studies and molecular targets

SL Cruz, MT Rivera-García… - Journal of drug and …, 2014 - ncbi.nlm.nih.gov
It has long been known that individuals will engage in voluntary inhalation of volatile
solvents for their rewarding effects. However, research into the neurobiology of these agents …

Translating neurobehavioural endpoints of developmental neurotoxicity tests into in vitro assays and readouts

C van Thriel, RHS Westerink, C Beste, AS Bale… - Neurotoxicology, 2012 - Elsevier
The developing nervous system is particularly vulnerable to chemical insults. Exposure to
chemicals can result in neurobehavioural alterations, and these have been used as …

Severe, multimodal stress exposure induces PTSD-like characteristics in a mouse model of single prolonged stress

SA Perrine, AL Eagle, SA George, K Mulo… - Behavioural Brain …, 2016 - Elsevier
Appropriate animal models of posttraumatic stress disorder (PTSD) are needed because
human studies remain limited in their ability to probe the underlying neurobiology of PTSD …

Ketamine reverses stress-induced depression-like behavior and increased GABA levels in the anterior cingulate: an 11.7 T 1H-MRS study in rats

SA Perrine, F Ghoddoussi, MS Michaels… - Progress in Neuro …, 2014 - Elsevier
Gamma-aminobutyric acid (GABA) is the major inhibitory amino acid neurotransmitter in the
brain and is primarily responsible for modulating excitatory tone. Clinical neuroimaging …

Abuse-like toluene exposure during early adolescence alters subsequent ethanol and cocaine behavioral effects and brain monoamines in male mice

CJ Davidson, JH Hannigan, SA Perrine… - Neurotoxicology and …, 2024 - Elsevier
Currently, there is a gap in understanding the neurobiological impact early adolescent
toluene exposure has on subsequent actions of other drugs. Adolescent (PND 28–32) male …

Effect of acute exposure to toluene on cortical excitability, neuroplasticity, and motor learning in healthy humans

F Yavari, C van Thriel, MA Nitsche, MF Kuo - Archives of toxicology, 2018 - Springer
Toluene is a well-known neurotoxic organic solvent and a major component of many
industrial and commercial products such as adhesives, paint thinners and gasoline. Many …

Applications of high‐resolution magic angle spinning MRS in biomedical studies I—cell line and animal models

E Kaebisch, TL Fuss, LA Vandergrift… - NMR in …, 2017 - Wiley Online Library
High‐resolution magic angle spinning (HRMAS) MRS allows for direct measurements of non‐
liquid tissue and cell specimens to present valuable insights into the cellular metabolisms of …

Toluene inhalation in adolescent rats reduces flexible behaviour in adulthood and alters glutamatergic and GABAergic signalling

TM Furlong, JR Duncan, LH Corbit… - Journal of …, 2016 - Wiley Online Library
Toluene is a commonly abused inhalant that is easily accessible to adolescents. Despite the
increasing incidence of use, our understanding of its long‐term impact remains limited …

Environmental enrichment reverses memory impairment induced by toluene in mice

S Montes, R del Carmen Solís-Guillén… - Neurotoxicology and …, 2017 - Elsevier
Toluene is the main component of a variety of inhalants that are used for intoxication
purposes. Alterations in memory have been reported in inhalant users; however, it is unclear …

Short-and long-term effects of chronic toluene exposure on recognition memory in adolescent and adult male Wistar rats

MG Zhvania, N Pochkhidze, M Dashniani, Y Tizabi… - Brain Research …, 2022 - Elsevier
Abuse of toluene-containing volatile inhalants, particularly among youth, is of significant
medical and social concern worldwide. Teenagers constitute the most abundant users of …