The need for new approaches to investigate ex vivo the causes and effects of tumor and to
achieve improved cancer treatments and medical therapies is particularly urgent for …

The efficiency of radiotherapy treatment regimes varies from tumour to tumour and from
patient to patient but it is generally highly influenced by the tumour microenvironment (TME) …

Simple Summary Transplantation of adult hematopoietic stem cells is an important
therapeutic tool to help patients suffering from diverse hematological disorders. All types of …

Human malignant hematopoietic stem and progenitor cells (HSPCs) reside in bone marrow
(BM) niches, which remain challenging to explore due to limited in vivo accessibility and …

Angiogenesis, the formation of new capillaries from existing ones, is a fundamental process
in regenerative medicine and tissue engineering. While it is known to be affected by …

With a very low survival rate, pancreatic ductal adenocarcinoma (PDAC) is a deadly
disease. This has been primarily attributed to (i) its late diagnosis and (ii) its high resistance …

Ex vivo studies of human disease, such as acute myeloid leukemia, are generally limited to
the analysis of two-dimensional cultures which often misinterpret the effectiveness of …

Simple Summary Pancreatic cancer challenges global health with non-specific symptoms,
devastatingly low survival rates, and high treatment resistance profiles. Tissue engineering …

Pancreatic ductal adenocarcinoma is an aggressive disease with an extremely low survival
rate. This is due to the (i) poor prognosis and (ii) high resistance of the disease to current …

Pancreatic ductal adenocarcinoma (PDAC) is a challenge for global health with very low
survival rate and high therapeutic resistance. Hence, advanced preclinical models for …