From gut microbiota to host appetite: gut microbiota-derived metabolites as key regulators

H Han, B Yi, R Zhong, M Wang, S Zhang, J Ma, Y Yin… - Microbiome, 2021 - Springer
Feelings of hunger and satiety are the key determinants for maintaining the life of humans
and animals. Disturbed appetite control may disrupt the metabolic health of the host and …

Gut microbiome, obesity, and metabolic dysfunction

H Tilg, A Kaser - The Journal of clinical investigation, 2011 - Am Soc Clin Investig
The prevalence of obesity and related disorders such as metabolic syndrome has vastly
increased throughout the world. Recent insights have generated an entirely new perspective …

Insights into the role of gut microbiota in obesity: pathogenesis, mechanisms, and therapeutic perspectives

L Sun, L Ma, Y Ma, F Zhang, C Zhao, Y Nie - Protein & cell, 2018 - academic.oup.com
Concern about health risks associated with rising obesity has become nearly universal, with
the mean body mass index (BMI) and the prevalence of obese and overweight individuals …

Hypothalamic AMPK: a canonical regulator of whole-body energy balance

M Lopez, R Nogueiras, M Tena-Sempere… - Nature Reviews …, 2016 - nature.com
AMP-activated protein kinase (AMPK) has a major role in the modulation of energy balance.
AMPK is activated in conditions of low energy, increasing energy production and reducing …

Hepatocyte-specific suppression of ANGPTL4 improves obesity-associated diabetes and mitigates atherosclerosis in mice

AK Singh, B Chaube, X Zhang, J Sun… - The Journal of …, 2021 - Am Soc Clin Investig
Hepatic uptake and biosynthesis of fatty acids (FAs), as well as the partitioning of FAs into
oxidative, storage, and secretory pathways, are tightly regulated processes. Dysregulation of …

Angiopoietin-like proteins: a comprehensive look

G Santulli - Frontiers in endocrinology, 2014 - frontiersin.org
Angiopoietin-like proteins (ANGPTLs) are a family of proteins structurally similar to the
angiopoietins. To date, eight ANGPTLs have been discovered, namely ANGPTL1 to …

Apple-derived pectin modulates gut microbiota, improves gut barrier function, and attenuates metabolic endotoxemia in rats with diet-induced obesity

T Jiang, X Gao, C Wu, F Tian, Q Lei, J Bi, B Xie… - Nutrients, 2016 - mdpi.com
This study was aimed at determining potential effects of apple-derived pectin on weight gain,
gut microbiota, gut barrier and metabolic endotoxemia in rat models of diet-induced obesity …

AMPK and the Endocrine Control of Metabolism

LK Townsend, GR Steinberg - Endocrine Reviews, 2023 - academic.oup.com
Complex multicellular organisms require a coordinated response from multiple tissues to
maintain whole-body homeostasis in the face of energetic stressors such as fasting, cold …

Gut microbiota in overweight and obesity: crosstalk with adipose tissue

PD Cani, M Van Hul - Nature Reviews Gastroenterology & Hepatology, 2024 - nature.com
Overweight and obesity are characterized by excessive fat mass accumulation produced
when energy intake exceeds energy expenditure. One plausible way to control energy …

Angiopoietin-like 4: a decade of research

P Zhu, YY Goh, HFA Chin, S Kersten… - Bioscience …, 2012 - portlandpress.com
The past decade has seen a rapid development and increasing recognition of ANGPTL4
(angiopoietin-like 4) as a remarkably multifaceted protein that is involved in many metabolic …