Congenital abnormalities of the kidney and urinary tract (CAKUT) occur in 1 out of 500
newborns, and constitute approximately 20–30% of all anomalies identified in the prenatal …

Fifteen years ago, this journal published a review outlining future options for regenerating
the kidney. At that time, stem cell populations were being identified in multiple tissues, the …

Recent advances in the generation of kidney organoids and the culture of primary nephron
progenitors from mouse and human have been based on knowledge of the molecular basis …

Abstract In late 2004, an International Consortium of research groups were charged with the
task of producing a high-quality molecular anatomy of the developing mammalian urogenital …

Short proteins play key roles in cell signalling and other processes, but their abundance in
the mammalian proteome is unknown. Current catalogues of mammalian proteins exhibit an …

The developmental activities of morphogens depend on the gradients that they form in the
extracellular matrix. Here, we show that differences in the binding of fibroblast growth factor …

Kidney development is based on differential cell-type-specific expression of a vast number
of genes. While multiple critical genes and pathways have been elucidated, a genome-wide …

All solid organs contain resident monocyte-derived cells that appear early in organogenesis
and persist throughout life. These cells are critical for normal development in some organs …

Histone deacetylases (HDACs) regulate fundamental biological processes such as cellular
proliferation, differentiation, and survival via genomic and nongenomic effects. This study …

Over a decade ago, it was proposed that the regulation of tubular repair in the kidney might
involve the recapitulation of developmental pathways. Although the kidney cannot generate …