Selenium is an essential immunonutrient which holds the human's metabolic activity with its
chemical bonds. The organic forms of selenium naturally present in human body are …

Here, we addressed the pharmacology and toxicology of synthetic organoselenium
compounds and some naturally occurring organoselenium amino acids. The use of …

The successful treatment of cancer has significantly improved as a result of targeted therapy
and immunotherapy. However, during chemotherapy, cancer cells evolve and can acquire …

Evading persistent drug resistance in cancer and bacteria is quintessential to restore health
in humans, and impels intervention strategies. A distinct property of the cancer phenotype is …

The cytosolic selenoprotein thioredoxin reductase 1 (TrxR1, TXNRD1), and to some extent
mitochondrial TrxR2 (TXNRD2), can be inhibited by a wide range of electrophilic …

Selenium (Se)-containing compounds have attracted a growing interest as anticancer
agents over recent decades, with mounting reports demonstrating their high efficacy and …

The high number of new cancer incidences and the associated mortality continue to be
alarming, leading to the search for new therapies that would be more effective and less …

The biological activity of selenium is dependent upon its speciation. We aim to integrate
selenium speciation and metabolism into a discussion of the mechanisms by which …

Ebselen is the leader of selenorganic compounds, and starting from its identification as
mimetic of the key antioxidant enzyme glutathione peroxidase, several papers have …

Selenium is an essential trace element that is crucial for cellular antioxidant defense against
reactive oxygen species (ROS). Recently, many selenium-containing compounds have …