Synthetic biomarkers: a twenty-first century path to early cancer detection
Detection of cancer at an early stage when it is still localized improves patient response to
medical interventions for most cancer types. The success of screening tools such as cervical …
medical interventions for most cancer types. The success of screening tools such as cervical …
The biology of brain metastases—translation to new therapies
AF Eichler, E Chung, DP Kodack, JS Loeffler… - Nature reviews Clinical …, 2011 - nature.com
Brain metastases are a serious obstacle in the treatment of patients with solid tumors and
contribute to the morbidity and mortality of these cancers. It is speculated that the frequency …
contribute to the morbidity and mortality of these cancers. It is speculated that the frequency …
[HTML][HTML] Aging of mice is associated with p16 (Ink4a)-and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells
Senescent cells (SCs) have been considered a source of age-related chronic sterile
systemic inflammation and a target for anti-aging therapies. To understand mechanisms …
systemic inflammation and a target for anti-aging therapies. To understand mechanisms …
Dendritic cell paucity in mismatch repair–proficient colorectal cancer liver metastases limits immune checkpoint blockade efficacy
WW Ho, IL Gomes-Santos, S Aoki… - Proceedings of the …, 2021 - National Acad Sciences
Liver metastasis is a major cause of mortality for patients with colorectal cancer (CRC).
Mismatch repair–proficient (pMMR) CRCs make up about 95% of metastatic CRCs, and are …
Mismatch repair–proficient (pMMR) CRCs make up about 95% of metastatic CRCs, and are …
Cancer imaging by optical coherence tomography: preclinical progress and clinical potential
The past decade has seen dramatic technological advances in the field of optical coherence
tomography (OCT) imaging. These advances have driven commercialization and clinical …
tomography (OCT) imaging. These advances have driven commercialization and clinical …
A brief review of bioluminescent systems (2019)
A Fleiss, KS Sarkisyan - Current genetics, 2019 - Springer
Despite being widely used in reporter technologies, bioluminescent systems are largely
understudied. Of at least forty different bioluminescent systems thought to exist in nature …
understudied. Of at least forty different bioluminescent systems thought to exist in nature …
Targeting miR-21 for the therapy of pancreatic cancer
F Sicard, M Gayral, H Lulka, L Buscail, P Cordelier - Molecular Therapy, 2013 - cell.com
Despite tremendous efforts worldwide from clinicians and cancer scientists, pancreatic
ductal adenocarcinoma (PDA) remains a deadly disease for which no cure is available …
ductal adenocarcinoma (PDA) remains a deadly disease for which no cure is available …
Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma
M Snuderl, A Batista, ND Kirkpatrick, CR de Almodovar… - Cell, 2013 - cell.com
Medulloblastoma is the most common pediatric malignant brain tumor. Although current
therapies improve survival, these regimens are highly toxic and are associated with …
therapies improve survival, these regimens are highly toxic and are associated with …
Ly6Clo monocytes drive immunosuppression and confer resistance to anti-VEGFR2 cancer therapy
Current anti-VEGF therapies for colorectal cancer (CRC) provide limited survival benefit, as
tumors rapidly develop resistance to these agents. Here, we have uncovered an …
tumors rapidly develop resistance to these agents. Here, we have uncovered an …
Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases
The survival benefit of anti–vascular endothelial growth factor (VEGF) therapy in metastatic
colorectal cancer (mCRC) patients is limited to a few months because of acquired …
colorectal cancer (mCRC) patients is limited to a few months because of acquired …