The enzyme lipoprotein lipase (LPL), originally identified as the clearing factor lipase,
hydrolyzes triglycerides present in the triglyceride-rich lipoproteins VLDL and chylomicrons …

Cardiovascular disease is the biggest killer globally and the principal contributing factor to
the pathology is atherosclerosis; a chronic, inflammatory disorder characterized by lipid and …

Transforming growth factor-β (TGF-β) superfamily members, TGF-β and bone
morphogenetic proteins (BMPs), are potent regulatory cytokines with diverse functions on …

Lipoprotein lipase (LPL) is a key enzyme in lipid metabolism and responsible for catalyzing
lipolysis of triglycerides in lipoproteins. LPL is produced mainly in adipose tissue, skeletal …

More than half of all patients with diabetes develop neuropathic disorders affecting the distal
sensory and/or motor nerves, or autonomic or cranial nerve functions. Glycemic control can …

Transforming growth factor-β (TGF-β) plays a pivotal role in a range of biological processes,
including the control of cellular proliferation and differentiation, regulation of tissue repair …

Genome-wide experimental methods to identify disease genes, such as linkage analysis
and association studies, generate increasingly large candidate gene sets for which …

Hormones are potent endo-, para-, and autocrine endogenous regulators of the function of
multiple organs, including the heart. Endocrine dysfunction promotes a number of …

Specificity protein (Sp) is a famous family of transcription factors including Sp1, Sp2 and
Sp3. Sp1 is the first one of Sp family proteins to be characterized and cloned in mammalian …

The proinflammatory cytokine IFN-γ is a master regulator of atherosclerosis and mediates its
cellular actions mainly through STAT1. Unfortunately, the impact of other IFN-γ inducible …